caa a22 4500 445883170 CHVBK 20180317145551.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s10157-011-0428-y doi (NATIONALLICENCE)springer-10.1007/s10157-011-0428-y The relationship between renal volume and renal function in autosomal dominant polycystic kidney disease [Elektronische Daten] [Shino Tokiwa, Satoru Muto, Toshiyuki China, Shigeo Horie] Background: In patients with autosomal dominant polycystic kidney disease (ADPKD), renal cysts grow exponentially. Since remaining renal parenchyma has a capacity to compensate for the loss of glomerular filtration, the glomerular filtration rate (GFR) may be sustained until the disease progresses. The purpose of this study was to determine if renal volumetric indices and clinical parameters are associated with renal function in Japanese patients with ADPKD. Methods: In 73 ADPKD patients (28 men, 45 women), the associations of mean systolic blood pressure, mean diastolic blood pressure, estimated GFR (eGFR), the amount of proteinuria and albuminuria, body mass index (BMI), brachial-ankle pulse wave velocity (baPWV), ankle-brachial index, and total kidney volume (TKV) were retrospectively analyzed. Results: Multivariate linear regression analysis showed that eGFR was significantly and independently inversely correlated with patients' age and BMI. The median change in eGFR per year (ΔeGFR/y) was −2.8ml/min/1.73m2/year. Multiple linear regression analysis showed that ΔeGFR/y was significantly and independently inversely correlated with the change in TKV per year (ΔTKV/y). Multiple linear regression analysis showed that ΔTKV/y was significantly related to initial TKV and the change in albuminuria per year. Conclusions: This study demonstrated a significant relationship between the change in renal function and the change in renal volume in Japanese ADPKD patients without renal insufficiency. It is possible that the volume measurements can be used as useful markers for disease progression in Japanese ADPKD patients. Japanese Society of Nephrology, 2011 Autosomal dominant polycystic kidney disease nationallicence Renal function nationallicence Renal volume nationallicence Marker nationallicence Tokiwa Shino Department of Urology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, 173-8605, Tokyo, Japan aut Muto Satoru Department of Urology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, 173-8605, Tokyo, Japan aut China Toshiyuki Department of Urology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, 173-8605, Tokyo, Japan aut Horie Shigeo Department of Urology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, 173-8605, Tokyo, Japan aut Clinical and Experimental Nephrology Springer Japan 15/4(2011-08-01), 539-545 1342-1751 15:4<539 2011 15 10157 https://doi.org/10.1007/s10157-011-0428-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10157-011-0428-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tokiwa Shino Department of Urology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, 173-8605, Tokyo, Japan aut NATIONALLICENCE 700 1- Muto Satoru Department of Urology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, 173-8605, Tokyo, Japan aut NATIONALLICENCE 700 1- China Toshiyuki Department of Urology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, 173-8605, Tokyo, Japan aut NATIONALLICENCE 700 1- Horie Shigeo Department of Urology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, 173-8605, Tokyo, Japan aut NATIONALLICENCE 773 0- Clinical and Experimental Nephrology Springer Japan 15/4(2011-08-01), 539-545 1342-1751 15:4<539 2011 15 10157 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer