caa a22 4500 445883189 CHVBK 20180317145551.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s10157-011-0459-4 doi (NATIONALLICENCE)springer-10.1007/s10157-011-0459-4 Lung injury following acute kidney injury: kidney-lung crosstalk [Elektronische Daten] [Kent Doi, Tomoko Ishizu, Toshiro Fujita, Eisei Noiri] The mortality of acute kidney injury (AKI) remains unacceptably high, especially associated with acute respiratory failure. Lung injury complicated with AKI was previously considered as "uremic lung”, which is characterized by volume overload and increased vascular permeability. New experimental data using rodent models of renal ischemia-reperfusion and bilateral nephrectomy have emerged recently focusing on kidney-lung crosstalk in AKI, and have highlighted the pathophysiological significance of increased cytokine concentration, enhanced inflammatory responses, and neutrophil activation. In this review, we outline the history of uremic lung and acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), the epidemiological data on the synergistic effect of AKI and lung injury on mortality, and recent basic research which has identified possible pathways in AKI-induced lung injury. These findings will enable us to develop new therapeutic strategies against lung injury associated with AKI and improve the outcomes of critically ill patients in intensive care units. Japanese Society of Nephrology, 2011 Acute kidney injury nationallicence Acute lung injury nationallicence Ischemia reperfusion nationallicence Bilateral nephrectomy nationallicence Neutrophil elastase nationallicence Doi Kent Nephrology and Endocrinology, Hemodialysis and Apheresis, University Hospital, The University of Tokyo, Tokyo, Japan aut Ishizu Tomoko Nephrology and Endocrinology, Hemodialysis and Apheresis, University Hospital, The University of Tokyo, Tokyo, Japan aut Fujita Toshiro Nephrology and Endocrinology, Hemodialysis and Apheresis, University Hospital, The University of Tokyo, Tokyo, Japan aut Noiri Eisei Nephrology and Endocrinology, Hemodialysis and Apheresis, University Hospital, The University of Tokyo, Tokyo, Japan aut Clinical and Experimental Nephrology Springer Japan 15/4(2011-08-01), 464-470 1342-1751 15:4<464 2011 15 10157 https://doi.org/10.1007/s10157-011-0459-4 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10157-011-0459-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Doi Kent Nephrology and Endocrinology, Hemodialysis and Apheresis, University Hospital, The University of Tokyo, Tokyo, Japan aut NATIONALLICENCE 700 1- Ishizu Tomoko Nephrology and Endocrinology, Hemodialysis and Apheresis, University Hospital, The University of Tokyo, Tokyo, Japan aut NATIONALLICENCE 700 1- Fujita Toshiro Nephrology and Endocrinology, Hemodialysis and Apheresis, University Hospital, The University of Tokyo, Tokyo, Japan aut NATIONALLICENCE 700 1- Noiri Eisei Nephrology and Endocrinology, Hemodialysis and Apheresis, University Hospital, The University of Tokyo, Tokyo, Japan aut NATIONALLICENCE 773 0- Clinical and Experimental Nephrology Springer Japan 15/4(2011-08-01), 464-470 1342-1751 15:4<464 2011 15 10157 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer