caa a22 4500 445883243 CHVBK 20180317145551.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s10157-011-0440-2 doi (NATIONALLICENCE)springer-10.1007/s10157-011-0440-2 Predictors of acute kidney injury post-cardiopulmonary bypass in children [Elektronische Daten] [Sidharth Sethi, Deepak Goyal, Dinesh Yadav, Umesh Shukla, Pyare Kajala, V. Gupta, Vijay Grover, Pragati Kapoor, Atul Juneja] Objective: To investigate the incidence, implicating factors and outcome of acute kidney injury (AKI) after cardiopulmonary bypass (CPB) in patients admitted to a pediatric cardiothoracic intensive care unit (ICU). Materials and methods: Design: A retrospective review study. Setting: A 10-bed cardiothoracic ICU. Patients: One hundred and twenty-four children (<18years of age) admitted to the cardiothoracic ICU following CPB between January 2007 and December 2009. Methods: Age, sex, diagnosis, baseline and post-surgery hemoglobin, total leukocyte count, platelet count and biochemistry were recorded. Baseline and postoperative urea (mg/dl), creatinine (mg/dl), urine output (ml/kg/h) and inotrope dose were also recorded daily. The duration of CPB was noted. Postoperative cardiac, renal, hepatic, neurologic and respiratory dysfunctions were recorded. Results: Seven (5%) children developed AKI stage I, five children (4%) developed AKI stage II and two children developed AKI stage III (2%). All patients with AKI had a longer stay in hospital and increased mortality. Two children required dialysis for AKI and none developed chronic renal impairment. All patients with AKI stage III died during the ICU stay. Using stepwise regression, younger age (<1year), weight <10kg, pump failure, sepsis and duration of CPB >90min were significant risk factors identified for developing AKI. Conclusions: AKI is common and occurred in 11% of our patients following CPB; however, AKI requiring renal replacement therapy is uncommon. Japanese Society of Nephrology, 2011 Acute kidney injury nationallicence Acute renal failure nationallicence Cardiac surgery nationallicence Congenital heart disease nationallicence Pediatric intensive care nationallicence Cardiopulmonary bypass nationallicence Sethi Sidharth Department of Pediatrics, PGIMER and Associated RML Hospital, 110001, New Delhi, India aut Goyal Deepak Department of Pediatrics, PGIMER and Associated RML Hospital, 110001, New Delhi, India aut Yadav Dinesh Department of Pediatrics, PGIMER and Associated RML Hospital, 110001, New Delhi, India aut Shukla Umesh Department of Pediatrics, PGIMER and Associated RML Hospital, 110001, New Delhi, India aut Kajala Pyare Department of Pediatrics, PGIMER and Associated RML Hospital, 110001, New Delhi, India aut Gupta V. Department of Cardiothoracic and Vascular Surgery, PGIMER and Associated RML Hospital, 110001, New Delhi, India aut Grover Vijay Department of Cardiothoracic and Vascular Surgery, PGIMER and Associated RML Hospital, 110001, New Delhi, India aut Kapoor Pragati Department of Cardiothoracic and Vascular Surgery, PGIMER and Associated RML Hospital, 110001, New Delhi, India aut Juneja Atul National Institute of Medical Statistics, Indian Council of Medical Research, 110029, New Delhi, India aut Clinical and Experimental Nephrology Springer Japan 15/4(2011-08-01), 529-534 1342-1751 15:4<529 2011 15 10157 https://doi.org/10.1007/s10157-011-0440-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10157-011-0440-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sethi Sidharth Department of Pediatrics, PGIMER and Associated RML Hospital, 110001, New Delhi, India aut NATIONALLICENCE 700 1- Goyal Deepak Department of Pediatrics, PGIMER and Associated RML Hospital, 110001, New Delhi, India aut NATIONALLICENCE 700 1- Yadav Dinesh Department of Pediatrics, PGIMER and Associated RML Hospital, 110001, New Delhi, India aut NATIONALLICENCE 700 1- Shukla Umesh Department of Pediatrics, PGIMER and Associated RML Hospital, 110001, New Delhi, India aut NATIONALLICENCE 700 1- Kajala Pyare Department of Pediatrics, PGIMER and Associated RML Hospital, 110001, New Delhi, India aut NATIONALLICENCE 700 1- Gupta V. Department of Cardiothoracic and Vascular Surgery, PGIMER and Associated RML Hospital, 110001, New Delhi, India aut NATIONALLICENCE 700 1- Grover Vijay Department of Cardiothoracic and Vascular Surgery, PGIMER and Associated RML Hospital, 110001, New Delhi, India aut NATIONALLICENCE 700 1- Kapoor Pragati Department of Cardiothoracic and Vascular Surgery, PGIMER and Associated RML Hospital, 110001, New Delhi, India aut NATIONALLICENCE 700 1- Juneja Atul National Institute of Medical Statistics, Indian Council of Medical Research, 110029, New Delhi, India aut NATIONALLICENCE 773 0- Clinical and Experimental Nephrology Springer Japan 15/4(2011-08-01), 529-534 1342-1751 15:4<529 2011 15 10157 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer