caa a22 4500 445883251 CHVBK 20180317145551.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s10157-011-0454-9 doi (NATIONALLICENCE)springer-10.1007/s10157-011-0454-9 Evidence-based statin prescription for cardiovascular protection in renal impairment [Elektronische Daten] [Fabio Fabbian, Alfredo De Giorgi, Marco Pala, Ruana Tiseo, Roberto Manfredini, Francesco Portaluppi] Dyslipidemia is a well-known risk factor for cardiovascular disease in the general population, and the cardioprotective role of statins is well established. However, although cardiovascular disease is the major cause of morbidity and mortality in chronic kidney disease (CKD), the role of statin therapy is still under investigation. In CKD the atherosclerotic burden is high and pathophysiology of dyslipidemia is complex; however, the majority of large-scale statin trials excluded patients with CKD. Statins could have different effects in the different stages of CKD. Two large trials involving haemodialysis patients showed unfavourable results, whereas in renal transplant subjects as well as in early CKD subjects, statins reduced cardiovascular risk. The studies involving early CKD patients are post-hoc analyses of large trials and they showed that statins are more effective in secondary than in primary prevention. The aim of this study was to evaluate the effectiveness of statins for prevention of cardiovascular events by calculating the number of patients needed to be treated in different interventional trials. We conclude that dyslipidemia is a modifiable cardiovascular risk and statins appear to be an effective treatment especially in the early stages of CKD. Patients on renal replacement therapy could obtain an advantage from this treatment; however, the patient's clinical prognosis should be taken into account when evaluating treatment. Japanese Society of Nephrology, 2011 Chronic renal failure nationallicence Statins nationallicence Cardiovascular disease nationallicence Number needed to treat nationallicence Fabbian Fabio Department of Clinical and Experimental Medicine, Section of Clinica Medica, University of Ferrara, Azienda Ospedaliera-Universitaria ‘S.Anna', Corso Giovecca, 203, 44123, Ferrara, Italy aut De Giorgi Alfredo Department of Clinical and Experimental Medicine, Section of Clinica Medica, University of Ferrara, Azienda Ospedaliera-Universitaria ‘S.Anna', Corso Giovecca, 203, 44123, Ferrara, Italy aut Pala Marco Department of Clinical and Experimental Medicine, Section of Clinica Medica, University of Ferrara, Azienda Ospedaliera-Universitaria ‘S.Anna', Corso Giovecca, 203, 44123, Ferrara, Italy aut Tiseo Ruana Department of Clinical and Experimental Medicine, Section of Clinica Medica, University of Ferrara, Azienda Ospedaliera-Universitaria ‘S.Anna', Corso Giovecca, 203, 44123, Ferrara, Italy aut Manfredini Roberto Department of Clinical and Experimental Medicine, Section of Clinica Medica, University of Ferrara, Azienda Ospedaliera-Universitaria ‘S.Anna', Corso Giovecca, 203, 44123, Ferrara, Italy aut Portaluppi Francesco Department of Clinical and Experimental Medicine, Section of Clinica Medica, University of Ferrara, Azienda Ospedaliera-Universitaria ‘S.Anna', Corso Giovecca, 203, 44123, Ferrara, Italy aut Clinical and Experimental Nephrology Springer Japan 15/4(2011-08-01), 456-463 1342-1751 15:4<456 2011 15 10157 https://doi.org/10.1007/s10157-011-0454-9 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10157-011-0454-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fabbian Fabio Department of Clinical and Experimental Medicine, Section of Clinica Medica, University of Ferrara, Azienda Ospedaliera-Universitaria ‘S.Anna', Corso Giovecca, 203, 44123, Ferrara, Italy aut NATIONALLICENCE 700 1- De Giorgi Alfredo Department of Clinical and Experimental Medicine, Section of Clinica Medica, University of Ferrara, Azienda Ospedaliera-Universitaria ‘S.Anna', Corso Giovecca, 203, 44123, Ferrara, Italy aut NATIONALLICENCE 700 1- Pala Marco Department of Clinical and Experimental Medicine, Section of Clinica Medica, University of Ferrara, Azienda Ospedaliera-Universitaria ‘S.Anna', Corso Giovecca, 203, 44123, Ferrara, Italy aut NATIONALLICENCE 700 1- Tiseo Ruana Department of Clinical and Experimental Medicine, Section of Clinica Medica, University of Ferrara, Azienda Ospedaliera-Universitaria ‘S.Anna', Corso Giovecca, 203, 44123, Ferrara, Italy aut NATIONALLICENCE 700 1- Manfredini Roberto Department of Clinical and Experimental Medicine, Section of Clinica Medica, University of Ferrara, Azienda Ospedaliera-Universitaria ‘S.Anna', Corso Giovecca, 203, 44123, Ferrara, Italy aut NATIONALLICENCE 700 1- Portaluppi Francesco Department of Clinical and Experimental Medicine, Section of Clinica Medica, University of Ferrara, Azienda Ospedaliera-Universitaria ‘S.Anna', Corso Giovecca, 203, 44123, Ferrara, Italy aut NATIONALLICENCE 773 0- Clinical and Experimental Nephrology Springer Japan 15/4(2011-08-01), 456-463 1342-1751 15:4<456 2011 15 10157 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer