caa a22 4500 445883308 CHVBK 20180317145551.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s10157-011-0446-9 doi (NATIONALLICENCE)springer-10.1007/s10157-011-0446-9 Measurements of serum cystatin C concentrations underestimate renal dysfunction in pediatric patients with chronic kidney disease [Elektronische Daten] [Osamu Uemura, Katsumi Ushijima, Takuhito Nagai, Takuji Yamada, Satoshi Yamakawa, Yoshiko Hibi, Hideki Hayakawa, Yayoi Nabeta, Yoshiko Shinkai, Kouichi Koike, Masaki Kuwabara] Background: In our clinical experience, cystatin C (CysC) concentrations are not as high as expected in patients with chronic kidney disease (CKD) and high-stage renal dysfunction. We therefore investigated whether measurements of serum CysC result in an underestimation of renal dysfunction in pediatric patients with CKD. Methods: Glomerular filtration rate (GFR) was estimated from serum creatinine (Cr) concentration, using the equation Cr-GFR (%)=[0.30×body length (m)/serum Cr]×100; and from serum CysC concentration, using the equation Cys-GFR (%)=(0.70/serum CysC)×100. We investigated the relationship between GFR estimated by these 2 equations. Patients aged 2-12years were assorted into 5 groups, based on GFR-Cr categories of <12.5, ≥12.5 to <25, ≥25 to <50, ≥50 to <75, and ≥75%, and GFR-CysC/GFR-Cr ratios were compared in these 5 groups. Results: The median GFR-CysC/GFR-Cr ratio in groups of patients with GFR-Cr of <12.5, ≥12.5 to <25, ≥25 to <50, ≥50 to <75, and ≥75% were 2.28, 1.48, 1.22, 1.18 and 0.98, respectively, with statistically significant differences between any two groups (p<0.001). Conclusion: Measurements of serum CysC concentrations lead to underestimation of renal dysfunction in pediatric patients with CKD. Japanese Society of Nephrology, 2011 Serum cystatin C level nationallicence Pediatric chronic kidney disease nationallicence CKD nationallicence Renal dysfunction nationallicence Uemura Osamu Department of Pediatric Nephrology, Aichi Children's Health and Medical Center, 1-2 Osakada, Morioka-cho, 474-8710, Obu, Aichi, Japan aut Ushijima Katsumi Department of Pediatric Nephrology, Aichi Children's Health and Medical Center, 1-2 Osakada, Morioka-cho, 474-8710, Obu, Aichi, Japan aut Nagai Takuhito Department of Pediatric Nephrology, Aichi Children's Health and Medical Center, 1-2 Osakada, Morioka-cho, 474-8710, Obu, Aichi, Japan aut Yamada Takuji Department of Pediatric Nephrology, Aichi Children's Health and Medical Center, 1-2 Osakada, Morioka-cho, 474-8710, Obu, Aichi, Japan aut Yamakawa Satoshi Department of Pediatric Nephrology, Aichi Children's Health and Medical Center, 1-2 Osakada, Morioka-cho, 474-8710, Obu, Aichi, Japan aut Hibi Yoshiko Department of Pediatric Nephrology, Aichi Children's Health and Medical Center, 1-2 Osakada, Morioka-cho, 474-8710, Obu, Aichi, Japan aut Hayakawa Hideki Department of Clinical Laboratory, Aichi Children's Health and Medical Center, Obu, Japan aut Nabeta Yayoi Department of Clinical Laboratory, Aichi Children's Health and Medical Center, Obu, Japan aut Shinkai Yoshiko Department of Clinical Laboratory, Aichi Children's Health and Medical Center, Obu, Japan aut Koike Kouichi Department of Clinical Laboratory, Aichi Children's Health and Medical Center, Obu, Japan aut Kuwabara Masaki Department of Clinical Laboratory, Aichi Children's Health and Medical Center, Obu, Japan aut Clinical and Experimental Nephrology Springer Japan 15/4(2011-08-01), 535-538 1342-1751 15:4<535 2011 15 10157 https://doi.org/10.1007/s10157-011-0446-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10157-011-0446-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Uemura Osamu Department of Pediatric Nephrology, Aichi Children's Health and Medical Center, 1-2 Osakada, Morioka-cho, 474-8710, Obu, Aichi, Japan aut NATIONALLICENCE 700 1- Ushijima Katsumi Department of Pediatric Nephrology, Aichi Children's Health and Medical Center, 1-2 Osakada, Morioka-cho, 474-8710, Obu, Aichi, Japan aut NATIONALLICENCE 700 1- Nagai Takuhito Department of Pediatric Nephrology, Aichi Children's Health and Medical Center, 1-2 Osakada, Morioka-cho, 474-8710, Obu, Aichi, Japan aut NATIONALLICENCE 700 1- Yamada Takuji Department of Pediatric Nephrology, Aichi Children's Health and Medical Center, 1-2 Osakada, Morioka-cho, 474-8710, Obu, Aichi, Japan aut NATIONALLICENCE 700 1- Yamakawa Satoshi Department of Pediatric Nephrology, Aichi Children's Health and Medical Center, 1-2 Osakada, Morioka-cho, 474-8710, Obu, Aichi, Japan aut NATIONALLICENCE 700 1- Hibi Yoshiko Department of Pediatric Nephrology, Aichi Children's Health and Medical Center, 1-2 Osakada, Morioka-cho, 474-8710, Obu, Aichi, Japan aut NATIONALLICENCE 700 1- Hayakawa Hideki Department of Clinical Laboratory, Aichi Children's Health and Medical Center, Obu, Japan aut NATIONALLICENCE 700 1- Nabeta Yayoi Department of Clinical Laboratory, Aichi Children's Health and Medical Center, Obu, Japan aut NATIONALLICENCE 700 1- Shinkai Yoshiko Department of Clinical Laboratory, Aichi Children's Health and Medical Center, Obu, Japan aut NATIONALLICENCE 700 1- Koike Kouichi Department of Clinical Laboratory, Aichi Children's Health and Medical Center, Obu, Japan aut NATIONALLICENCE 700 1- Kuwabara Masaki Department of Clinical Laboratory, Aichi Children's Health and Medical Center, Obu, Japan aut NATIONALLICENCE 773 0- Clinical and Experimental Nephrology Springer Japan 15/4(2011-08-01), 535-538 1342-1751 15:4<535 2011 15 10157 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer