caa a22 4500 445883316 CHVBK 20180317145551.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s10157-011-0441-1 doi (NATIONALLICENCE)springer-10.1007/s10157-011-0441-1 Kidney function, albuminuria and cardiovascular risk factors in post-operative living kidney donors: a single-center, cross-sectional study [Elektronische Daten] [Masahiko Yazawa, Ryo Kido, Yugo Shibagaki, Takashi Yasuda, Ryuto Nakazawa, Hideo Sasaki, Yuichi Sato, Tatsuya Chikaraishi, Kenjiro Kimura] Background: Mortality and renal or cardiovascular prognosis in living kidney donors (LKDs) has been reported to be as same as the general population; however, it is known that the prevalence of hypertension, albuminuria and metabolic syndrome increases after donation. At present, data from Japanese donors are scarce and as a result the actual medical status of LKDs remains unclear. To evaluate cardiovascular disease (CVD) risk factors in Japanese LKDs, we conducted a cross-sectional study on LKDs at our tertiary care hospital and clinic. Method: Thirty-six out of 63 LKDs who underwent kidney donation at the kidney disease center of the St. Marianna University Hospital were enrolled. The kidney function, albuminuria, and CVD risk factors including hypertension, dyslipidemia, hyperuricemia, glucose intolerance (GI) and obesity were cross-sectionally investigated. Results: The kidney function by inulin clearance was 55.2±10.3ml/min/1.73m2 on average, indicating that 63.9% of LKDs were categorized into chronic kidney disease (CKD) stage 3 after donation. Albuminuria developed in 16.7%. Blood pressure (BP) was not elevated after donation, but ambulatory BP monitoring revealed that 39.4% of LKDs were categorized as having non-dipper type BP. GI was shown in 25% of LKDs. Prevalence of dyslipidemia and hyperuricemia were 41.7% and 27.8%, respectively. Body mass index was not significantly changed after donation. Seven LKDs (19.4%) were diagnosed with metabolic syndrome. Conclusion: Many Japanese LKDs were experiencing decreased kidney function corresponding to CKD stage 3. They also had a significant but not lower prevalence of albuminuria and CVD risk compared to the general Japanese population. LKDs should be followed closely with special attention to the management of renal and CVD risk factors. Japanese Society of Nephrology, 2011 Living kidney donor nationallicence Cardiovascular risk factor nationallicence Kidney function nationallicence Albuminuria nationallicence Yazawa Masahiko Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, 216-8511, Kawasaki, Kanagawa, Japan aut Kido Ryo Department of Epidemiology and Healthcare Research, Kyoto University, School of Public Health, Kyoto, Japan aut Shibagaki Yugo Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, 216-8511, Kawasaki, Kanagawa, Japan aut Yasuda Takashi Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, 216-8511, Kawasaki, Kanagawa, Japan aut Nakazawa Ryuto Department of Urology, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan aut Sasaki Hideo Department of Urology, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan aut Sato Yuichi Department of Urology, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan aut Chikaraishi Tatsuya Department of Urology, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan aut Kimura Kenjiro Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, 216-8511, Kawasaki, Kanagawa, Japan aut Clinical and Experimental Nephrology Springer Japan 15/4(2011-08-01), 514-521 1342-1751 15:4<514 2011 15 10157 https://doi.org/10.1007/s10157-011-0441-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10157-011-0441-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yazawa Masahiko Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, 216-8511, Kawasaki, Kanagawa, Japan aut NATIONALLICENCE 700 1- Kido Ryo Department of Epidemiology and Healthcare Research, Kyoto University, School of Public Health, Kyoto, Japan aut NATIONALLICENCE 700 1- Shibagaki Yugo Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, 216-8511, Kawasaki, Kanagawa, Japan aut NATIONALLICENCE 700 1- Yasuda Takashi Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, 216-8511, Kawasaki, Kanagawa, Japan aut NATIONALLICENCE 700 1- Nakazawa Ryuto Department of Urology, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan aut NATIONALLICENCE 700 1- Sasaki Hideo Department of Urology, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan aut NATIONALLICENCE 700 1- Sato Yuichi Department of Urology, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan aut NATIONALLICENCE 700 1- Chikaraishi Tatsuya Department of Urology, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan aut NATIONALLICENCE 700 1- Kimura Kenjiro Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, 216-8511, Kawasaki, Kanagawa, Japan aut NATIONALLICENCE 773 0- Clinical and Experimental Nephrology Springer Japan 15/4(2011-08-01), 514-521 1342-1751 15:4<514 2011 15 10157 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer