caa a22 4500 445883324 CHVBK 20180317145551.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s10157-011-0462-9 doi (NATIONALLICENCE)springer-10.1007/s10157-011-0462-9 Hirohata Shunsei Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, 1-15-1 Kitasato, Minamiku, 252-0374, Sagamihara, Kanagawa, Japan aut Anti-ribosomal P antibodies and lupus nephritis [Elektronische Daten] [Shunsei Hirohata] Increasing attention has been paid to the relationship of autoantibodies to ribosomal P proteins (anti-P) with lupus nephritis. Several mechanisms of involvement of anti-P in lupus nephritis have been proposed, including cross-reactivity with anti-dsDNA and anti-endothelial cell antibodies (AECA). In addition, it is also suggested that anti-P might play a role in the development of lupus nephritis through induction of T helper 1 responses. Of note, recent studies have disclosed that the presence of isolated anti-P antibodies may discriminate patients with pure class V lupus nephritis, whereas the simultaneous presence of anti-dsDNA antibodies suggests class V disease with concomitant proliferative lesions. These observations lead to the hypothesis that anti-P and anti-dsDNA might result in membraneous changes and proliferative changes, respectively, although further investigation is required for confirmation. Japanese Society of Nephrology, 2011 Systemic lupus erythematosus nationallicence Pathogenesis nationallicence Lupus nephritis nationallicence Anti-DNA antibodies nationallicence Anti-ribosomal P antibodies nationallicence Clinical and Experimental Nephrology Springer Japan 15/4(2011-08-01), 471-477 1342-1751 15:4<471 2011 15 10157 https://doi.org/10.1007/s10157-011-0462-9 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10157-011-0462-9 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Hirohata Shunsei Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, 1-15-1 Kitasato, Minamiku, 252-0374, Sagamihara, Kanagawa, Japan aut NATIONALLICENCE 773 0- Clinical and Experimental Nephrology Springer Japan 15/4(2011-08-01), 471-477 1342-1751 15:4<471 2011 15 10157 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer