caa a22 4500 445883340 CHVBK 20180317145551.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s10157-011-0460-y doi (NATIONALLICENCE)springer-10.1007/s10157-011-0460-y Roles of organic anion/cation transporters at the blood-brain and blood-cerebrospinal fluid barriers involving uremic toxins [Elektronische Daten] [Ken-ichi Hosoya, Masanori Tachikawa] The blood-brain barrier (BBB) and blood-cerebrospinal fluid barrier (BCSFB) play key roles in the influx and efflux transport of endogenous substrates in the brain and cerebrospinal fluid. The organic anion transporter (OAT) 3 and organic cation transporter (OCT) 3, which belong to the solute carrier (SLC) 22A family, are expressed at the BBB and BCSFB, and regulate the excretion of endogenous and exogenous organic anions and cations. Our recent research provides novel molecular and functional evidence that indoxyl sulfate, an anionic uremic toxin, undergoes efflux transport at the BBB via OAT3 and creatinine, a uremic guanidino compound, undergoes efflux transport at the BCSFB via OCT3. Renal impairment is associated with the accumulation of uremic toxins in blood and uremic encephalopathy. It is conceivable that uremic encephalopathy is related to inhibition or dysfunction of efflux transport systems for uremic toxins in the brain. Here, we review the function of OAT3 and OCT3 at the BBB and BCSFB in the context of their roles in the progression of renal failure. Japanese Society of Nephrology, 2011 Blood-brain barrier nationallicence Blood-cerebrospinal fluid barrier nationallicence Creatinine nationallicence Indoxyl sulfate nationallicence Organic anion transporter nationallicence Organic cation transporter nationallicence Hosoya Ken-ichi Department of Pharmaceutics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630, Sugitani, 930-0194, Toyama, Japan aut Tachikawa Masanori Department of Pharmaceutics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630, Sugitani, 930-0194, Toyama, Japan aut Clinical and Experimental Nephrology Springer Japan 15/4(2011-08-01), 478-485 1342-1751 15:4<478 2011 15 10157 https://doi.org/10.1007/s10157-011-0460-y text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10157-011-0460-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hosoya Ken-ichi Department of Pharmaceutics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630, Sugitani, 930-0194, Toyama, Japan aut NATIONALLICENCE 700 1- Tachikawa Masanori Department of Pharmaceutics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630, Sugitani, 930-0194, Toyama, Japan aut NATIONALLICENCE 773 0- Clinical and Experimental Nephrology Springer Japan 15/4(2011-08-01), 478-485 1342-1751 15:4<478 2011 15 10157 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer