caa a22 4500 445883375 CHVBK 20180317145551.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s10157-011-0422-4 doi (NATIONALLICENCE)springer-10.1007/s10157-011-0422-4 Risk factors for metabolic syndrome in stable Italian renal transplant patients [Elektronische Daten] [Fabio Fabbian, Maurizio Bergami, Christian Molino, Alfredo De Giorgi, Marco Pala, Carlo Longhini, Francesco Portaluppi] Background: The prevalence of metabolic syndrome (MS) in renal transplant recipients (RTR) is still under investigation. Methods: We performed a cross-sectional study of 107 stable RTR who were diagnosed as having MS defined by the Adult Treatment Panel III of the National Cholesterol Education Program (NCEP-ATP III) criteria. Anthropometric, clinical and biochemical data were collected. Results: Mean age of the patients studied was 55±11years (72 male, 35 female), dialysis duration before transplantation 30±31months, time since transplantation 42±13months. Mean serum creatinine was 1.68±0.64mg/dl; creatinine clearance by Cockcroft-Gault formula53±20ml/min, glomerular filtration rate by 4-variable MDRD formula48±18ml/min/1.73m2. Thirty-seven patients (34.5%) had MS. The MS patients had higher weight (76±13 vs. 68±12kg, p=0.0033), body mass index (BMI) (26±4 vs. 24±3kg/m2, p=0.0025), waist circumference (101±11 vs. 90±11cm, p<0.0001), prevalence of BMI >25k/m2 (57 vs. 34%, p=0.0254), prevalence of diabetes mellitus before transplantation (8 vs. 0%, p=0.0157), glycaemia (104±31 vs. 87±11mg/dl, p=0.0002), and triglyceridaemia (225±105 vs. 112±35mg/dl, p<0.0001). They also showed lower levels of high-density lipoprotein cholesterol (48±15 vs. 68±17mg/dl, p<0.0001). Multiple logistic regression analysis showed that only BMI was independently associated with MS (OR 1.21, 95% CI 1.06-1.37, p=0.0037). Conclusions: MS according to NCEP-ATP III criteria appears to be present in about one-third of RTR, and even small increases in BMI above 25kg/m2 may determine the presence of MS in these patients. Therefore the preventive value of lifestyle modifications is very important for such patients, in order to strictly maintain body fat accumulation within the normal range. Japanese Society of Nephrology, 2011 Metabolic syndrome nationallicence Body mass index nationallicence Renal transplant recipients nationallicence Renal graft function nationallicence Fabbian Fabio Department of Clinical and Experimental Medicine, University Hospital "St. Anna”, University of Ferrara, Corso Giovecca, 203, 44123, Ferrara, Italy aut Bergami Maurizio Renal Unit, University Hospital "St. Anna”, Ferrara, Italy aut Molino Christian Department of Clinical and Experimental Medicine, University Hospital "St. Anna”, University of Ferrara, Corso Giovecca, 203, 44123, Ferrara, Italy aut De Giorgi Alfredo Department of Clinical and Experimental Medicine, University Hospital "St. Anna”, University of Ferrara, Corso Giovecca, 203, 44123, Ferrara, Italy aut Pala Marco Department of Clinical and Experimental Medicine, University Hospital "St. Anna”, University of Ferrara, Corso Giovecca, 203, 44123, Ferrara, Italy aut Longhini Carlo Department of Clinical and Experimental Medicine, University Hospital "St. Anna”, University of Ferrara, Corso Giovecca, 203, 44123, Ferrara, Italy aut Portaluppi Francesco Department of Clinical and Experimental Medicine, University Hospital "St. Anna”, University of Ferrara, Corso Giovecca, 203, 44123, Ferrara, Italy aut Clinical and Experimental Nephrology Springer Japan 15/4(2011-08-01), 560-566 1342-1751 15:4<560 2011 15 10157 https://doi.org/10.1007/s10157-011-0422-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10157-011-0422-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fabbian Fabio Department of Clinical and Experimental Medicine, University Hospital "St. Anna”, University of Ferrara, Corso Giovecca, 203, 44123, Ferrara, Italy aut NATIONALLICENCE 700 1- Bergami Maurizio Renal Unit, University Hospital "St. Anna”, Ferrara, Italy aut NATIONALLICENCE 700 1- Molino Christian Department of Clinical and Experimental Medicine, University Hospital "St. Anna”, University of Ferrara, Corso Giovecca, 203, 44123, Ferrara, Italy aut NATIONALLICENCE 700 1- De Giorgi Alfredo Department of Clinical and Experimental Medicine, University Hospital "St. Anna”, University of Ferrara, Corso Giovecca, 203, 44123, Ferrara, Italy aut NATIONALLICENCE 700 1- Pala Marco Department of Clinical and Experimental Medicine, University Hospital "St. Anna”, University of Ferrara, Corso Giovecca, 203, 44123, Ferrara, Italy aut NATIONALLICENCE 700 1- Longhini Carlo Department of Clinical and Experimental Medicine, University Hospital "St. Anna”, University of Ferrara, Corso Giovecca, 203, 44123, Ferrara, Italy aut NATIONALLICENCE 700 1- Portaluppi Francesco Department of Clinical and Experimental Medicine, University Hospital "St. Anna”, University of Ferrara, Corso Giovecca, 203, 44123, Ferrara, Italy aut NATIONALLICENCE 773 0- Clinical and Experimental Nephrology Springer Japan 15/4(2011-08-01), 560-566 1342-1751 15:4<560 2011 15 10157 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer