caa a22 4500 445883391 CHVBK 20180317145551.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s10157-011-0475-4 doi (NATIONALLICENCE)springer-10.1007/s10157-011-0475-4 Urinary angiotensinogen as a predictive marker in patients with immunoglobulin A nephropathy [Elektronische Daten] [Yang-Gyun Kim, Se-Bin Song, Sang-Ho Lee, Ju-Young Moon, Kyung-Hwan Jeong, Tae-Won Lee, Chun-Gyoo Ihm] Background: The intrarenal renin−angiotensinogen system (RAS) plays a major role in the progression of chronic kidney disease. Urinary angiotensinogen (UAGT) provides a specific index of the intrarenal RAS status. This study was conducted to find the role of UAGT as a predictive marker in patients with immunoglobulin A nephropathy (IgAN). Methods: Thirty-six patients with IgAN, 14 non-IgAN and 15 healthy controls were included. The UAGT concentration was measured using human ELISA kits and adjusted by urinary creatinine. Results: UAGT levels were significantly higher in patients with IgAN and non-IgAN than in healthy subjects (104.96 vs. 6.71ng/mgCr, p<0.01). Using univariate regression analysis, UAGT was found to correlate with the urine protein-to-creatinine ratio (UPCR), serum creatinine, and systolic and diastolic blood pressure in patients with IgAN. Multivariate regression analysis revealed that UAGT correlated positively with UPCR. Patients with levels of UAGT >100ng/mgCr showed higher serum creatinine after treatment than patients with UAGT levels <100ng/mgCr. Conclusion: This study showed that UAGT levels are increased and correlate positively with the UPCR in IgAN. Patients with high levels of UAGT may have poor renal function following treatment. Japanese Society of Nephrology, 2011 Urinary angiotensinogen nationallicence IgA nephropathy nationallicence Renal function nationallicence Kim Yang-Gyun Division of Nephrology, Kyung Hee University School of Medicine, Seoul, Korea aut Song Se-Bin Division of Nephrology, Kyung Hee University School of Medicine, Seoul, Korea aut Lee Sang-Ho Division of Nephrology, Kyung Hee University School of Medicine, Seoul, Korea aut Moon Ju-Young Division of Nephrology, Kyung Hee University School of Medicine, Seoul, Korea aut Jeong Kyung-Hwan Division of Nephrology, Kyung Hee University School of Medicine, Seoul, Korea aut Lee Tae-Won Division of Nephrology, Kyung Hee University School of Medicine, Seoul, Korea aut Ihm Chun-Gyoo Division of Nephrology, Kyung Hee University School of Medicine, Seoul, Korea aut Clinical and Experimental Nephrology Springer Japan 15/5(2011-10-01), 720-726 1342-1751 15:5<720 2011 15 10157 https://doi.org/10.1007/s10157-011-0475-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10157-011-0475-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kim Yang-Gyun Division of Nephrology, Kyung Hee University School of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Song Se-Bin Division of Nephrology, Kyung Hee University School of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Lee Sang-Ho Division of Nephrology, Kyung Hee University School of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Moon Ju-Young Division of Nephrology, Kyung Hee University School of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Jeong Kyung-Hwan Division of Nephrology, Kyung Hee University School of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Lee Tae-Won Division of Nephrology, Kyung Hee University School of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Ihm Chun-Gyoo Division of Nephrology, Kyung Hee University School of Medicine, Seoul, Korea aut NATIONALLICENCE 773 0- Clinical and Experimental Nephrology Springer Japan 15/5(2011-10-01), 720-726 1342-1751 15:5<720 2011 15 10157 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer