caa a22 4500 44588343X CHVBK 20180317145551.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s10157-011-0467-4 doi (NATIONALLICENCE)springer-10.1007/s10157-011-0467-4 Metabolomic profiling of the autosomal dominant polycystic kidney disease rat model [Elektronische Daten] [Takafumi Toyohara, Takehiro Suzuki, Yasutoshi Akiyama, Daisuke Yoshihara, Yoichi Takeuchi, Eikan Mishima, Koichi Kikuchi, Chitose Suzuki, Masayuki Tanemoto, Sadayoshi Ito, Shizuko Nagao, Tomoyoshi Soga, Takaaki Abe] Background: Autosomal dominant polycystic kidney disease (ADPKD) is an inherited systemic disease characterized by renal cyst expansion, resulting in renal failure. With the progression of renal damage, the accumulation of uremic compounds is recently reported to subsequently cause further renal damage and hypertension. Finding uremic toxins and sensitive markers for detecting the early stage of ADPKD is necessary to clarify its pathophysiological process and to prevent its progression. The aim of this study was to analyze the profile of uremic retention solutes of ADPKD by capillary electrophoresis-mass spectrometry (CE-MS) using the Han:SPRD rat model. Methods: Two hundred and ninety-seven cations and 190 anions were comprehensively analyzed by CE-MS in Han:SPRD rats and control rats. Results: We found 21 cations and 19 anions that accumulated significantly in the heterozygous (Cy/+) ADPKD rat model compared with control rats. Among the compounds, increases in 5-methyl-2′-deoxycytidine, glucosamine, ectoine, allantoate, α-hydroxybenzoate, phenaceturate and 3-phenylpropionate and decreases in 2-deoxycytidine, decanoate and 10-hydroxydecanoate were newly identified in the ADPKD Cy/+ rats. Conclusion: We identified uremic retention solutes in ADPKD Cy/+ rats. Compounds related to ADPKD could be useful markers for detecting the early stage of ADPKD. Japanese Society of Nephrology, 2011 Uremic toxin nationallicence ADPKD nationallicence CE-MS nationallicence Biomarker nationallicence Toyohara Takafumi Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University, Graduate School of Medicine, 980-8574, Sendai, Japan aut Suzuki Takehiro Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University, Graduate School of Medicine, 980-8574, Sendai, Japan aut Akiyama Yasutoshi Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University, Graduate School of Medicine, 980-8574, Sendai, Japan aut Yoshihara Daisuke Education and Research Center of Animal Models for Human Diseases, Fujita Health University, 470-1192, Toyoake, Japan aut Takeuchi Yoichi Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University, Graduate School of Medicine, 980-8574, Sendai, Japan aut Mishima Eikan Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University, Graduate School of Medicine, 980-8574, Sendai, Japan aut Kikuchi Koichi Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University, Graduate School of Medicine, 980-8574, Sendai, Japan aut Suzuki Chitose Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University, Graduate School of Medicine, 980-8574, Sendai, Japan aut Tanemoto Masayuki Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University, Graduate School of Medicine, 980-8574, Sendai, Japan aut Ito Sadayoshi Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University, Graduate School of Medicine, 980-8574, Sendai, Japan aut Nagao Shizuko Education and Research Center of Animal Models for Human Diseases, Fujita Health University, 470-1192, Toyoake, Japan aut Soga Tomoyoshi Institute for Advanced Biosciences, Keio University, 997-0052, Tsuruoka, Japan aut Abe Takaaki Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University, Graduate School of Medicine, 980-8574, Sendai, Japan aut Clinical and Experimental Nephrology Springer Japan 15/5(2011-10-01), 676-687 1342-1751 15:5<676 2011 15 10157 https://doi.org/10.1007/s10157-011-0467-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10157-011-0467-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Toyohara Takafumi Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University, Graduate School of Medicine, 980-8574, Sendai, Japan aut NATIONALLICENCE 700 1- Suzuki Takehiro Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University, Graduate School of Medicine, 980-8574, Sendai, Japan aut NATIONALLICENCE 700 1- Akiyama Yasutoshi Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University, Graduate School of Medicine, 980-8574, Sendai, Japan aut NATIONALLICENCE 700 1- Yoshihara Daisuke Education and Research Center of Animal Models for Human Diseases, Fujita Health University, 470-1192, Toyoake, Japan aut NATIONALLICENCE 700 1- Takeuchi Yoichi Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University, Graduate School of Medicine, 980-8574, Sendai, Japan aut NATIONALLICENCE 700 1- Mishima Eikan Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University, Graduate School of Medicine, 980-8574, Sendai, Japan aut NATIONALLICENCE 700 1- Kikuchi Koichi Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University, Graduate School of Medicine, 980-8574, Sendai, Japan aut NATIONALLICENCE 700 1- Suzuki Chitose Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University, Graduate School of Medicine, 980-8574, Sendai, Japan aut NATIONALLICENCE 700 1- Tanemoto Masayuki Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University, Graduate School of Medicine, 980-8574, Sendai, Japan aut NATIONALLICENCE 700 1- Ito Sadayoshi Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University, Graduate School of Medicine, 980-8574, Sendai, Japan aut NATIONALLICENCE 700 1- Nagao Shizuko Education and Research Center of Animal Models for Human Diseases, Fujita Health University, 470-1192, Toyoake, Japan aut NATIONALLICENCE 700 1- Soga Tomoyoshi Institute for Advanced Biosciences, Keio University, 997-0052, Tsuruoka, Japan aut NATIONALLICENCE 700 1- Abe Takaaki Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University, Graduate School of Medicine, 980-8574, Sendai, Japan aut NATIONALLICENCE 773 0- Clinical and Experimental Nephrology Springer Japan 15/5(2011-10-01), 676-687 1342-1751 15:5<676 2011 15 10157 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer