caa a22 4500 445883545 CHVBK 20180317145552.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s10157-011-0477-2 doi (NATIONALLICENCE)springer-10.1007/s10157-011-0477-2 Membranous nephropathy in an HIV-positive patient complicated with hepatitis B virus infection [Elektronische Daten] [Akihiko Numata, Tetsu Akimoto, Masaki Toshima, Yoshitaka Iwazu, Naoko Otani, Takuya Miki, Taro Sugase, Osamu Saito, Yoshitomo Hamano, Fumi Takemoto, Yoshihiko Ueda, Shigeaki Muto, Eiji Kusano] In ordinary settings, human immunodeficiency virus (HIV)-associated nephropathy should be considered when HIV infection is associated with heavy proteinuria. On the other hand, hepatitis B virus (HBV) may also play a role in the development of glomerular injury among patients with HIV infection, since HIV and HBV infections commonly occur together due to shared modes of transmission. We present here a case of nephrotic syndrome in an HIV-positive patient complicated with HBV infection. A renal biopsy revealed sparse granular deposits of immunoglobulin G in the subepithelial region, consistent with membranous nephropathy (MN) stage I. Moreover, immunostaining exhibited weak anti-hepatitis B core activity within glomeruli. These results led us to consider that HBV-associated MN might play a role in the development of nephrotic syndrome. Although anti-viral treatment for patients with HBV-associated MN has been suggested to be clinically effective, the use of two anti-HIV agents (tenofovir and emtricitabine), both of which have anti-HBV activities, was not effective for the patient's nephrotic syndrome, despite obtaining a decrease in the serum HBV-DNA levels. A lack of prospective data suggests that many decisions on the treatment of glomerulopathies with HIV infections are potentially empirical. Obviously, further studies and accumulated clinical experience are required to better determine the pathogenesis and management of HBV-associated MN among patients with HIV infections. Japanese Society of Nephrology, 2011 HIV nationallicence HBV nationallicence HAART nationallicence Membranous nephropathy nationallicence HBV reactivation nationallicence Numata Akihiko Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Akimoto Tetsu Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Toshima Masaki Division of Hematology, Department of Internal Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Iwazu Yoshitaka Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Otani Naoko Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Miki Takuya Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Sugase Taro Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Saito Osamu Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Hamano Yoshitomo Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Takemoto Fumi Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Ueda Yoshihiko Department of Diagnostic Pathology, Dokkyo Medical University Koshigaya Hospital, 2-1-50 Minamikoshigaya, 343-8555, Koshigaya, Saitama, Japan aut Muto Shigeaki Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Kusano Eiji Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Clinical and Experimental Nephrology Springer Japan 15/5(2011-10-01), 769-773 1342-1751 15:5<769 2011 15 10157 https://doi.org/10.1007/s10157-011-0477-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10157-011-0477-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Numata Akihiko Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Akimoto Tetsu Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Toshima Masaki Division of Hematology, Department of Internal Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Iwazu Yoshitaka Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Otani Naoko Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Miki Takuya Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Sugase Taro Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Saito Osamu Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Hamano Yoshitomo Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Takemoto Fumi Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Ueda Yoshihiko Department of Diagnostic Pathology, Dokkyo Medical University Koshigaya Hospital, 2-1-50 Minamikoshigaya, 343-8555, Koshigaya, Saitama, Japan aut NATIONALLICENCE 700 1- Muto Shigeaki Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Kusano Eiji Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 773 0- Clinical and Experimental Nephrology Springer Japan 15/5(2011-10-01), 769-773 1342-1751 15:5<769 2011 15 10157 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer