caa a22 4500 445883553 CHVBK 20180317145552.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s10157-011-0452-y doi (NATIONALLICENCE)springer-10.1007/s10157-011-0452-y Age, gender, and body length effects on reference serum creatinine levels determined by an enzymatic method in Japanese children: a multicenter study [Elektronische Daten] [Osamu Uemura, Masataka Honda, Takeshi Matsuyama, Kenji Ishikura, Hiroshi Hataya, Nahoko Yata, Takuhito Nagai, Yohei Ikezumi, Naoya Fujita, Shuichi Ito, Kazumoto Iijima, Teruo Kitagawa] Background: Enzymatic methods have recently been used to measure creatinine (Cr) instead of the Jaffe method. Therefore, it is necessary to determine the reference serum Cr value for these enzymatic methods to evaluate renal function in Japanese children. Methods: To determine reference values of serum Cr in Japanese children, 1151 children (517 male, 634 female) aged between 1 month and 18 years had their serum Cr values measured by an enzymatic method. To be included in the study the children had to be without kidney disease, urogenital disease, infectious disease, inflammatory disease, dehydration, muscular disease, anomaly syndrome, cardiovascular disease, malignant disease, hypertension, liver or pancreas disease, or pregnancy. Results: The medians of reference values increased gradually with age, i.e., 0.30mg/dl at 4years old and 0.41mg/dl at 10years old. In adolescence, they increased significantly more rapidly in males than in females. We found a linear regression equation capable of estimating the reference value of serum Cr in children aged 2-11years, and quintic regression equations capable of estimating the reference values of serum Cr in male and female children of all ages. Conclusion: The reference serum Cr levels determined by an enzymatic method related to age, gender, and body length, and our linear and polynomial equations showing the relationship between body length and serum Cr level will be applicable for screening of renal function in Asian as well as Japanese children. Japanese Society of Nephrology, 2011 Reference serum creatinine level nationallicence Japanese children nationallicence Enzymatic method nationallicence Body length nationallicence eGFR nationallicence Uemura Osamu The Japanese Society for Pediatric Nephrology, The Committee of Measures for Pediatric CKD, Tokyo, Japan aut Honda Masataka The Japanese Society for Pediatric Nephrology, The Committee of Measures for Pediatric CKD, Tokyo, Japan aut Matsuyama Takeshi The Japanese Society for Pediatric Nephrology, The Committee of Measures for Pediatric CKD, Tokyo, Japan aut Ishikura Kenji The Japanese Society for Pediatric Nephrology, The Committee of Measures for Pediatric CKD, Tokyo, Japan aut Hataya Hiroshi The Japanese Society for Pediatric Nephrology, The Committee of Measures for Pediatric CKD, Tokyo, Japan aut Yata Nahoko The Japanese Society for Pediatric Nephrology, The Committee of Measures for Pediatric CKD, Tokyo, Japan aut Nagai Takuhito The Japanese Society for Pediatric Nephrology, The Committee of Measures for Pediatric CKD, Tokyo, Japan aut Ikezumi Yohei The Japanese Society for Pediatric Nephrology, The Committee of Measures for Pediatric CKD, Tokyo, Japan aut Fujita Naoya The Japanese Society for Pediatric Nephrology, The Committee of Measures for Pediatric CKD, Tokyo, Japan aut Ito Shuichi The Japanese Society for Pediatric Nephrology, The Committee of Measures for Pediatric CKD, Tokyo, Japan aut Iijima Kazumoto The Japanese Society for Pediatric Nephrology, The Committee of Measures for Pediatric CKD, Tokyo, Japan aut Kitagawa Teruo Tokyo Health Service Association, Tokyo, Japan aut Clinical and Experimental Nephrology Springer Japan 15/5(2011-10-01), 694-699 1342-1751 15:5<694 2011 15 10157 https://doi.org/10.1007/s10157-011-0452-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10157-011-0452-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Uemura Osamu The Japanese Society for Pediatric Nephrology, The Committee of Measures for Pediatric CKD, Tokyo, Japan aut NATIONALLICENCE 700 1- Honda Masataka The Japanese Society for Pediatric Nephrology, The Committee of Measures for Pediatric CKD, Tokyo, Japan aut NATIONALLICENCE 700 1- Matsuyama Takeshi The Japanese Society for Pediatric Nephrology, The Committee of Measures for Pediatric CKD, Tokyo, Japan aut NATIONALLICENCE 700 1- Ishikura Kenji The Japanese Society for Pediatric Nephrology, The Committee of Measures for Pediatric CKD, Tokyo, Japan aut NATIONALLICENCE 700 1- Hataya Hiroshi The Japanese Society for Pediatric Nephrology, The Committee of Measures for Pediatric CKD, Tokyo, Japan aut NATIONALLICENCE 700 1- Yata Nahoko The Japanese Society for Pediatric Nephrology, The Committee of Measures for Pediatric CKD, Tokyo, Japan aut NATIONALLICENCE 700 1- Nagai Takuhito The Japanese Society for Pediatric Nephrology, The Committee of Measures for Pediatric CKD, Tokyo, Japan aut NATIONALLICENCE 700 1- Ikezumi Yohei The Japanese Society for Pediatric Nephrology, The Committee of Measures for Pediatric CKD, Tokyo, Japan aut NATIONALLICENCE 700 1- Fujita Naoya The Japanese Society for Pediatric Nephrology, The Committee of Measures for Pediatric CKD, Tokyo, Japan aut NATIONALLICENCE 700 1- Ito Shuichi The Japanese Society for Pediatric Nephrology, The Committee of Measures for Pediatric CKD, Tokyo, Japan aut NATIONALLICENCE 700 1- Iijima Kazumoto The Japanese Society for Pediatric Nephrology, The Committee of Measures for Pediatric CKD, Tokyo, Japan aut NATIONALLICENCE 700 1- Kitagawa Teruo Tokyo Health Service Association, Tokyo, Japan aut NATIONALLICENCE 773 0- Clinical and Experimental Nephrology Springer Japan 15/5(2011-10-01), 694-699 1342-1751 15:5<694 2011 15 10157 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer