caa a22 4500 445883634 CHVBK 20180317145552.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s10157-011-0474-5 doi (NATIONALLICENCE)springer-10.1007/s10157-011-0474-5 A case of hypokalemia-induced fatal arrhythmia caused by indapamide in an anorexic elderly patient [Elektronische Daten] [Naro Ohashi, Shoko Minemura, Akashi Togawa, Kunio Ohyama] An 84-year-old man was referred to our hospital for atrioventricular block and severe hypokalemia. He had been treated for hypertension since 2007 with indapamide, a thiazide-like diuretic. His laboratory data had not been tested for a long time. One week before his first visit, he suffered from a common cold and anorexia. He was admitted to our hospital because his electrocardiogram showed ventricular flutter, and pulmonary arrest occurred at the time of his visit. Cardiopulmonary resuscitation was successfully performed. Hypokalemia (K, 1.7mEq/L) was considered as the cause of acute cardiopulmonary failure. His oral intake of potassium decreased, but potassium loss from the kidney persisted (urinary potassium, 14.0mEq/L; transtubular potassium gradient, 5.00). These results suggested that although hypokalemia was suspected to have been present for a long time due to indapamide, severe hypokalemia was induced during the period of anorexia. After discontinuation of indapamide and intravenous administration of potassium l-aspartate for potassium supplementation, the patient's serum potassium levels increased and his general condition improved. Although it is well known that hypokalemia is caused by indapamide, the incidence is not frequent and if observed is not severe. However, we experienced an unusual case of hypokalemia-induced fatal arrhythmia caused by indapamide. Hence, the serum potassium concentration of patients under the drug, especially anorexic elderly patients, should be monitored. Japanese Society of Nephrology, 2011 Hypokalemia nationallicence Indapamide nationallicence Anorexic elderly patients nationallicence Ohashi Naro Department of Nephrology, Numazu City Hospital, 550 Higashishiiji Azaharunoki, 410-0302, Numazu, Japan aut Minemura Shoko Department of Gastroenterology, Numazu City Hospital, 550 Higashishiiji Azaharunoki, 410-0302, Numazu, Japan aut Togawa Akashi Department of Nephrology, Numazu City Hospital, 550 Higashishiiji Azaharunoki, 410-0302, Numazu, Japan aut Ohyama Kunio Department of Nephrology, Numazu City Hospital, 550 Higashishiiji Azaharunoki, 410-0302, Numazu, Japan aut Clinical and Experimental Nephrology Springer Japan 15/5(2011-10-01), 761-764 1342-1751 15:5<761 2011 15 10157 https://doi.org/10.1007/s10157-011-0474-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10157-011-0474-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ohashi Naro Department of Nephrology, Numazu City Hospital, 550 Higashishiiji Azaharunoki, 410-0302, Numazu, Japan aut NATIONALLICENCE 700 1- Minemura Shoko Department of Gastroenterology, Numazu City Hospital, 550 Higashishiiji Azaharunoki, 410-0302, Numazu, Japan aut NATIONALLICENCE 700 1- Togawa Akashi Department of Nephrology, Numazu City Hospital, 550 Higashishiiji Azaharunoki, 410-0302, Numazu, Japan aut NATIONALLICENCE 700 1- Ohyama Kunio Department of Nephrology, Numazu City Hospital, 550 Higashishiiji Azaharunoki, 410-0302, Numazu, Japan aut NATIONALLICENCE 773 0- Clinical and Experimental Nephrology Springer Japan 15/5(2011-10-01), 761-764 1342-1751 15:5<761 2011 15 10157 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer