caa a22 4500 445883650 CHVBK 20180317145552.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s10157-011-0451-z doi (NATIONALLICENCE)springer-10.1007/s10157-011-0451-z Protective effect of beta-glucan on contrast induced-nephropathy and a comparison of beta-glucan with nebivolol and N -acetylcysteine in rats [Elektronische Daten] [Eyup Koc, Kadriye Reis, Fatma Ebinc, Hatice Pasaoglu, Canan Demirtas, Suna Omeroglu, Ulver Derici, Galip Guz, Yasemin Erten, Musa Bali, Turgay Arinsoy, Sukru Sindel] Background: It has been shown that beta-glucan (BG), which has antioxidant and immunomodulatory effects, attenuats renal ischemia-reperfusion injury. We aimed to investigate whether BG might have a preventive role against the development of contrast-induced nephropathy and to compare its effect with nebivolol (Nb) and N-acetylcysteine (NAC). Methods: Thirty-six Wistar albino female rats were randomly divided into six groups (n=6 each): control, contrast media (CM), BG, BG+CM, Nb+CM, and NAC+CM. With the exception of control and CM groups, the others were given drugs orally once a day for 5days. Kidney function parameters, inflammatory parameters, and serum and renal tissue oxidative stress markers were measured. Results: Increases of serum creatinine and blood urea nitrogen levels were significantly higher (p<0.05) in the CM group only. Absolute changes of serum creatinine levels in BG, BG+CM and Nb+CM groups were significantly lower than those in the CM group (p<0.05). Serum levels of advanced oxidation protein products and malondialdehyde were significantly less (p<0.05) in the BG group compared to the CM group. Histopathological lesions in the CM group were more advanced (p<0.05). No significant differences between the BG+CM, Nb+CM and NAC+CM groups were found with regard to histopathological findings. Conclusion: This study suggests that BG protects or ameliorates against contrast-induced nephropathy. Its beneficial effects may be similar to or greater than those of Nb or NAC. Japanese Society of Nephrology, 2011 Beta-glucan nationallicence Contrast nephropathy nationallicence N -acetylcysteine nationallicence Nebivolol nationallicence Oxidative stress nationallicence Koc Eyup Department of Nephrology, Ankara Numune Training and Research Hospital, Ankara, Turkey aut Reis Kadriye Department of Nephrology, Gazi University Medical School, Ankara, Turkey aut Ebinc Fatma Department of Nephrology, Gazi University Medical School, Ankara, Turkey aut Pasaoglu Hatice Department of Biochemistry, Gazi University Medical School, Ankara, Turkey aut Demirtas Canan Department of Biochemistry, Gazi University Medical School, Ankara, Turkey aut Omeroglu Suna Department of Histology, Gazi University Medical School, Ankara, Turkey aut Derici Ulver Department of Nephrology, Gazi University Medical School, Ankara, Turkey aut Guz Galip Department of Nephrology, Gazi University Medical School, Ankara, Turkey aut Erten Yasemin Department of Nephrology, Gazi University Medical School, Ankara, Turkey aut Bali Musa Department of Nephrology, Gazi University Medical School, Ankara, Turkey aut Arinsoy Turgay Department of Nephrology, Gazi University Medical School, Ankara, Turkey aut Sindel Sukru Department of Nephrology, Gazi University Medical School, Ankara, Turkey aut Clinical and Experimental Nephrology Springer Japan 15/5(2011-10-01), 658-665 1342-1751 15:5<658 2011 15 10157 https://doi.org/10.1007/s10157-011-0451-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10157-011-0451-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Koc Eyup Department of Nephrology, Ankara Numune Training and Research Hospital, Ankara, Turkey aut NATIONALLICENCE 700 1- Reis Kadriye Department of Nephrology, Gazi University Medical School, Ankara, Turkey aut NATIONALLICENCE 700 1- Ebinc Fatma Department of Nephrology, Gazi University Medical School, Ankara, Turkey aut NATIONALLICENCE 700 1- Pasaoglu Hatice Department of Biochemistry, Gazi University Medical School, Ankara, Turkey aut NATIONALLICENCE 700 1- Demirtas Canan Department of Biochemistry, Gazi University Medical School, Ankara, Turkey aut NATIONALLICENCE 700 1- Omeroglu Suna Department of Histology, Gazi University Medical School, Ankara, Turkey aut NATIONALLICENCE 700 1- Derici Ulver Department of Nephrology, Gazi University Medical School, Ankara, Turkey aut NATIONALLICENCE 700 1- Guz Galip Department of Nephrology, Gazi University Medical School, Ankara, Turkey aut NATIONALLICENCE 700 1- Erten Yasemin Department of Nephrology, Gazi University Medical School, Ankara, Turkey aut NATIONALLICENCE 700 1- Bali Musa Department of Nephrology, Gazi University Medical School, Ankara, Turkey aut NATIONALLICENCE 700 1- Arinsoy Turgay Department of Nephrology, Gazi University Medical School, Ankara, Turkey aut NATIONALLICENCE 700 1- Sindel Sukru Department of Nephrology, Gazi University Medical School, Ankara, Turkey aut NATIONALLICENCE 773 0- Clinical and Experimental Nephrology Springer Japan 15/5(2011-10-01), 658-665 1342-1751 15:5<658 2011 15 10157 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer