caa a22 4500 445883669 CHVBK 20180317145552.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s10157-011-0463-8 doi (NATIONALLICENCE)springer-10.1007/s10157-011-0463-8 Successful therapy with tonsillectomy for severe ISKDC grade VI Henoch-Schönlein purpura nephritis and persistent nephrotic syndrome [Elektronische Daten] [Shinichiro Ohara, Yukihiko Kawasaki, Hiromi Matsuura, Tomoko Oikawa, Kazuhide Suyama, Mitsuaki Hosoya] Henoch-Schönlein purpura (HSP) is a systemic disorder characterized by leukocytoclastic vasculitis involving the capillaries and the deposition of IgA immune complexes. Renal involvement is the principal cause of morbidity and mortality in children with HSP. We report here a 13-year-old girl with Henoch-Schönlein purpura nephritis (HSPN) of International Study of Kidney Disease in Children (ISKDC) grade VI and persistent nephrotic syndrome despite receiving conventional therapy, such as prednisolone, methylprednisolone and urokinase pulse therapy and plasmapheresis (PP). The patient was treated with tonsillectomy, which subsequently decreased proteinuria, induced the disappearance of microscopic hematuria, and improved renal pathological findings. A regimen of methylprednisolone and urokinase pulse therapy plus PP with tonsillectomy may be an effective and useful therapy for some children with severe HSPN children of ISKDC grade VI and persistent nephrotic syndrome. Japanese Society of Nephrology, 2011 Henoch-Schönlein purpura nephritis nationallicence Tonsillectomy methylprednisolone and urokinase pulse nationallicence Plasmapheresis nationallicence Nephrotic syndrome nationallicence Ohara Shinichiro Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikariga-oka, 960-1295, Fukushima, Fukushima, Japan aut Kawasaki Yukihiko Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikariga-oka, 960-1295, Fukushima, Fukushima, Japan aut Matsuura Hiromi Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikariga-oka, 960-1295, Fukushima, Fukushima, Japan aut Oikawa Tomoko Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikariga-oka, 960-1295, Fukushima, Fukushima, Japan aut Suyama Kazuhide Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikariga-oka, 960-1295, Fukushima, Fukushima, Japan aut Hosoya Mitsuaki Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikariga-oka, 960-1295, Fukushima, Fukushima, Japan aut Clinical and Experimental Nephrology Springer Japan 15/5(2011-10-01), 749-753 1342-1751 15:5<749 2011 15 10157 https://doi.org/10.1007/s10157-011-0463-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10157-011-0463-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ohara Shinichiro Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikariga-oka, 960-1295, Fukushima, Fukushima, Japan aut NATIONALLICENCE 700 1- Kawasaki Yukihiko Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikariga-oka, 960-1295, Fukushima, Fukushima, Japan aut NATIONALLICENCE 700 1- Matsuura Hiromi Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikariga-oka, 960-1295, Fukushima, Fukushima, Japan aut NATIONALLICENCE 700 1- Oikawa Tomoko Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikariga-oka, 960-1295, Fukushima, Fukushima, Japan aut NATIONALLICENCE 700 1- Suyama Kazuhide Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikariga-oka, 960-1295, Fukushima, Fukushima, Japan aut NATIONALLICENCE 700 1- Hosoya Mitsuaki Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikariga-oka, 960-1295, Fukushima, Fukushima, Japan aut NATIONALLICENCE 773 0- Clinical and Experimental Nephrology Springer Japan 15/5(2011-10-01), 749-753 1342-1751 15:5<749 2011 15 10157 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer