caa a22 4500 445883685 CHVBK 20180317145552.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s10157-010-0392-y doi (NATIONALLICENCE)springer-10.1007/s10157-010-0392-y The association between renal tubular damage and rapid renal deterioration in the Japanese population: the Takahata study [Elektronische Daten] [Kosuke Kudo, Tsuneo Konta, Yusuke Mashima, Kazunobu Ichikawa, Satoshi Takasaki, Ami Ikeda, Masato Hoshikawa, Kazuko Suzuki, Yoko Shibata, Tetsu Watanabe, Takeo Kato, Sumio Kawata, Isao Kubota] Background: Injury to renal tubules plays an important role in the development of various renal diseases; however, the prevalence and significance of renal tubular damage in the general population are unclear. To clarify this point, we conducted a community-based study, using urinary β2-microglobulin as a marker of tubular damage. Methods: The subjects studied were 3,444 Japanese over the age of 40years. The urinary β2-microglobulin-creatinine ratio (UBCR) was assessed in morning spot urine samples. Results: In this population, the distribution of the UBCR among these subjects was skewed towards higher values and a high UBCR (≥300μg/g) was identified in 438 (12.7%) subjects. However, overlap with macroalbuminuria and renal insufficiency [estimated glomerular filtration rate (eGFR) <60mL/min/1.73m2] was observed in only 25 (5.7%) and 58 (13.2%) of these subjects, respectively. Multivariate analysis indicated that a high UBCR was positively associated with aging, hypertension, macroalbuminuria and increased urinary sodium excretion. A 5-year longitudinal analysis in 899 subjects indicated a greater decline in eGFR in parallel with the increase in baseline UBCR. After adjustment for possible confounders, a high UBCR was an independent risk factor for rapid decline in eGFR [<−10mL/min/1.73m2; odds ratio 1.79 (95% confidence interval 1.07-2.99), P=0.026]. Conclusion: This study showed that renal tubular damage was common and was an independent risk factor for renal deterioration in the Japanese population. More attention should be paid to occult renal tubular damage in order to prevent end-stage renal disease. Japanese Society of Nephrology, 2010 β2-Microglobulin nationallicence General population nationallicence Renal insufficiency nationallicence Kudo Kosuke Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, 2-2-2, Iida-Nishi, 990-9585, Yamagata, Japan aut Konta Tsuneo Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, 2-2-2, Iida-Nishi, 990-9585, Yamagata, Japan aut Mashima Yusuke Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, 2-2-2, Iida-Nishi, 990-9585, Yamagata, Japan aut Ichikawa Kazunobu Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, 2-2-2, Iida-Nishi, 990-9585, Yamagata, Japan aut Takasaki Satoshi Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, 2-2-2, Iida-Nishi, 990-9585, Yamagata, Japan aut Ikeda Ami Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, 2-2-2, Iida-Nishi, 990-9585, Yamagata, Japan aut Hoshikawa Masato Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, 2-2-2, Iida-Nishi, 990-9585, Yamagata, Japan aut Suzuki Kazuko Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, 2-2-2, Iida-Nishi, 990-9585, Yamagata, Japan aut Shibata Yoko Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, 2-2-2, Iida-Nishi, 990-9585, Yamagata, Japan aut Watanabe Tetsu Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, 2-2-2, Iida-Nishi, 990-9585, Yamagata, Japan aut Kato Takeo Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetes, Yamagata University School of Medicine, Yamagata, Japan aut Kawata Sumio Department of Gastroenterology, Yamagata University School of Medicine, Yamagata, Japan aut Kubota Isao Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, 2-2-2, Iida-Nishi, 990-9585, Yamagata, Japan aut Clinical and Experimental Nephrology Springer Japan 15/2(2011-04-01), 235-241 1342-1751 15:2<235 2011 15 10157 https://doi.org/10.1007/s10157-010-0392-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10157-010-0392-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kudo Kosuke Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, 2-2-2, Iida-Nishi, 990-9585, Yamagata, Japan aut NATIONALLICENCE 700 1- Konta Tsuneo Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, 2-2-2, Iida-Nishi, 990-9585, Yamagata, Japan aut NATIONALLICENCE 700 1- Mashima Yusuke Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, 2-2-2, Iida-Nishi, 990-9585, Yamagata, Japan aut NATIONALLICENCE 700 1- Ichikawa Kazunobu Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, 2-2-2, Iida-Nishi, 990-9585, Yamagata, Japan aut NATIONALLICENCE 700 1- Takasaki Satoshi Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, 2-2-2, Iida-Nishi, 990-9585, Yamagata, Japan aut NATIONALLICENCE 700 1- Ikeda Ami Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, 2-2-2, Iida-Nishi, 990-9585, Yamagata, Japan aut NATIONALLICENCE 700 1- Hoshikawa Masato Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, 2-2-2, Iida-Nishi, 990-9585, Yamagata, Japan aut NATIONALLICENCE 700 1- Suzuki Kazuko Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, 2-2-2, Iida-Nishi, 990-9585, Yamagata, Japan aut NATIONALLICENCE 700 1- Shibata Yoko Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, 2-2-2, Iida-Nishi, 990-9585, Yamagata, Japan aut NATIONALLICENCE 700 1- Watanabe Tetsu Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, 2-2-2, Iida-Nishi, 990-9585, Yamagata, Japan aut NATIONALLICENCE 700 1- Kato Takeo Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetes, Yamagata University School of Medicine, Yamagata, Japan aut NATIONALLICENCE 700 1- Kawata Sumio Department of Gastroenterology, Yamagata University School of Medicine, Yamagata, Japan aut NATIONALLICENCE 700 1- Kubota Isao Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, 2-2-2, Iida-Nishi, 990-9585, Yamagata, Japan aut NATIONALLICENCE 773 0- Clinical and Experimental Nephrology Springer Japan 15/2(2011-04-01), 235-241 1342-1751 15:2<235 2011 15 10157 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE 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