caa a22 4500 44588374X CHVBK 20180317145553.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s10157-010-0395-8 doi (NATIONALLICENCE)springer-10.1007/s10157-010-0395-8 A case presenting with rapid renal damage caused by immunoglobulin D lambda-type multiple myeloma accompanied by granular lymphocyte proliferative disorder [Elektronische Daten] [Naro Ohashi, Kosuke Hirota, Akashi Togawa, Nobuharu Kosugi, Kunio Ohyama] A 69-year-old man was referred to our hospital for severe anemia. The atypical lymphocyte count, including granular lymphocytes, was 2,750/μL. Lymphocyte surface marker analysis showed CD3+, CD5+, CD16+, and CD56+ cells. Mixed T cell- and natural killer cell-type granular lymphocyte proliferative disorder (GLPD) was diagnosed. Because his serum creatinine levels deteriorated rapidly over the next 3months, from 0.96 to 3.27mg/dL, he was admitted to our hospital. The serum levels of immunoglobulins (Ig) other than IgD had decreased, and monoclonal protein was detected in the gamma-globulin region. Immunoelectrophoresis revealed IgD and lambda (λ) proteins in the serum and λ-type Bence-Jones protein in the urine. Renal biopsy examination revealed widespread tubular atrophy and interstitial fibrosis, and cast formation with λ protein deposits in tubular lumens, indicating cast nephropathy. These results indicated that the rapid renal damage was caused by IgD λ-type multiple myeloma accompanied by GLPD. The clinical course of GLPD is not usually aggressive and the findings of physical examinations are not significant. GLPD is usually associated with cytopenia (neutropenia or anemia), viral infections, collagen diseases, neoplasms such as malignant lymphoma, or chronic infections. To date, there are only 2 case reports of GLPD accompanied by multiple myeloma but without renal function or renal histological findings. When the clinical course of GLPD is aggressive and is accompanied with rapid renal damage, multiple myeloma should be considered as a complication. Japanese Society of Nephrology, 2010 Rapid renal damage nationallicence Multiple myeloma nationallicence Granular lymphocyte proliferative disorder nationallicence Ohashi Naro Department of Nephrology, Numazu City Hospital, 550 Higashishiiji Azaharunoki, 410-0302, Numazu, Japan aut Hirota Kosuke Department of Nephrology, Numazu City Hospital, 550 Higashishiiji Azaharunoki, 410-0302, Numazu, Japan aut Togawa Akashi Department of Nephrology, Numazu City Hospital, 550 Higashishiiji Azaharunoki, 410-0302, Numazu, Japan aut Kosugi Nobuharu Department of Hematology, Numazu City Hospital, 550 Higashishiiji Azaharunoki, 410-0302, Numazu, Japan aut Ohyama Kunio Department of Nephrology, Numazu City Hospital, 550 Higashishiiji Azaharunoki, 410-0302, Numazu, Japan aut Clinical and Experimental Nephrology Springer Japan 15/2(2011-04-01), 299-302 1342-1751 15:2<299 2011 15 10157 https://doi.org/10.1007/s10157-010-0395-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10157-010-0395-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ohashi Naro Department of Nephrology, Numazu City Hospital, 550 Higashishiiji Azaharunoki, 410-0302, Numazu, Japan aut NATIONALLICENCE 700 1- Hirota Kosuke Department of Nephrology, Numazu City Hospital, 550 Higashishiiji Azaharunoki, 410-0302, Numazu, Japan aut NATIONALLICENCE 700 1- Togawa Akashi Department of Nephrology, Numazu City Hospital, 550 Higashishiiji Azaharunoki, 410-0302, Numazu, Japan aut NATIONALLICENCE 700 1- Kosugi Nobuharu Department of Hematology, Numazu City Hospital, 550 Higashishiiji Azaharunoki, 410-0302, Numazu, Japan aut NATIONALLICENCE 700 1- Ohyama Kunio Department of Nephrology, Numazu City Hospital, 550 Higashishiiji Azaharunoki, 410-0302, Numazu, Japan aut NATIONALLICENCE 773 0- Clinical and Experimental Nephrology Springer Japan 15/2(2011-04-01), 299-302 1342-1751 15:2<299 2011 15 10157 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer