caa a22 4500 445883758 CHVBK 20180317145553.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s10157-010-0374-0 doi (NATIONALLICENCE)springer-10.1007/s10157-010-0374-0 Nitta Kosaku Department of Medicine, Kidney Center, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, 162-8666, Tokyo, Japan aut Pathogenesis and therapeutic implications of cardiorenal syndrome [Elektronische Daten] [Kosaku Nitta] Chronic kidney disease (CKD) is now widely accepted as a risk factor for cardiovascular disease and mortality. Heart failure patients with CKD have a worse prognosis. The heart and kidneys act in tandem to regulate blood pressure, vascular tone, diuresis, natriuresis, intravascular volume homeostasis, peripheral tissue perfusion, and oxygenation. Cardiorenal syndrome is a pathophysiological condition in which combined cardiac and renal dysfunction amplifies the progression of failure of the individual organs, and it has an extremely poor prognosis. The identification of patients and the pathophysiological mechanisms underlying each subtype will help physicians to understand the clinical derangements and provide the rationale for management strategies. The evidence from clinical trials conducted on heart failure patients with significant kidney dysfunction is insufficient because most patients are recruited from populations with relatively well-preserved kidney function. In severe volume-loaded patients who are refractory to diuretics and also have kidney dysfunction, the management of cardiorenal dysfunction is challenging, and effective therapy is lacking. In the absence of definitive clinical trials, treatment decisions must be based on a combination of information regarding the individual patient information and an understanding of the individual treatment options. Japanese Society of Nephrology, 2010 Chronic kidney disease nationallicence Cardiorenal syndrome nationallicence Heart failure nationallicence Rennin-angiotensin-aldosterone system nationallicence Anemia nationallicence Clinical and Experimental Nephrology Springer Japan 15/2(2011-04-01), 187-194 1342-1751 15:2<187 2011 15 10157 https://doi.org/10.1007/s10157-010-0374-0 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10157-010-0374-0 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Nitta Kosaku Department of Medicine, Kidney Center, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, 162-8666, Tokyo, Japan aut NATIONALLICENCE 773 0- Clinical and Experimental Nephrology Springer Japan 15/2(2011-04-01), 187-194 1342-1751 15:2<187 2011 15 10157 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer