caa a22 4500 445883812 CHVBK 20180317145553.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s10157-010-0380-2 doi (NATIONALLICENCE)springer-10.1007/s10157-010-0380-2 Children with posterior reversible encephalopathy syndrome associated with atypical diffusion-weighted imaging and apparent diffusion coefficient [Elektronische Daten] [Kenji Ishikura, Yuko Hamasaki, Tomoyuki Sakai, Hiroshi Hataya, Tomohide Goto, Sahoko Miyama, Tatsuo Kono, Masataka Honda] Posterior reversible encephalopathy syndrome (PRES) is a reversible, predominantly posterior, leukoencephalopathy associated with renal insufficiency, hypertension, or immunosuppressant drugs. We describe two children with PRES whose primary diagnoses were idiopathic nephrotic syndrome and lupus nephritis. Cranial magnetic resonance (MR) imaging at the onset of PRES showed strong hyperintense signals on diffusion-weighted imaging with restricted apparent diffusion coefficient values predominantly in the posterior region. Such findings have been rarely reported in children with PRES and initially suggested irreversible brain damage; however, both children fully recovered clinically as well as radiologically. Our findings suggest the limitations of cranial MR imaging for diagnosing PRES. Further experience with cranial MR imaging, including diffusion-weighted imaging with apparent diffusion coefficient mapping, is required to improve diagnostic accuracy and the ability to predict outcomes in patients with early-stage PRES. At present, initial imaging studies do not necessarily provide sufficient evidence for a firm diagnosis of PRES or the prediction of outcomes. Japanese Society of Nephrology, 2010 Posterior reversible encephalopathy syndrome nationallicence Diffusion-weighted imaging nationallicence Apparent diffusion coefficient values nationallicence Children nationallicence Nephrotic syndrome nationallicence Systemic lupus erythematosus nationallicence Ishikura Kenji Department of Pediatric Nephrology, Tokyo Metropolitan Children's Medical Center, 2-8-29 Musashidai, 183-8561, Fuchu, Tokyo, Japan aut Hamasaki Yuko Department of Pediatric Nephrology, Tokyo Metropolitan Children's Medical Center, 2-8-29 Musashidai, 183-8561, Fuchu, Tokyo, Japan aut Sakai Tomoyuki Department of Pediatric Nephrology, Tokyo Metropolitan Children's Medical Center, 2-8-29 Musashidai, 183-8561, Fuchu, Tokyo, Japan aut Hataya Hiroshi Department of Pediatric Nephrology, Tokyo Metropolitan Children's Medical Center, 2-8-29 Musashidai, 183-8561, Fuchu, Tokyo, Japan aut Goto Tomohide Department of Pediatric Neurology, Tokyo Metropolitan Children's Medical Center, Fuchu, Japan aut Miyama Sahoko Department of Pediatric Neurology, Tokyo Metropolitan Children's Medical Center, Fuchu, Japan aut Kono Tatsuo Department of Pediatric Radiology, Tokyo Metropolitan Children's Medical Center, Fuchu, Japan aut Honda Masataka Department of Pediatric Nephrology, Tokyo Metropolitan Children's Medical Center, 2-8-29 Musashidai, 183-8561, Fuchu, Tokyo, Japan aut Clinical and Experimental Nephrology Springer Japan 15/2(2011-04-01), 275-280 1342-1751 15:2<275 2011 15 10157 https://doi.org/10.1007/s10157-010-0380-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10157-010-0380-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ishikura Kenji Department of Pediatric Nephrology, Tokyo Metropolitan Children's Medical Center, 2-8-29 Musashidai, 183-8561, Fuchu, Tokyo, Japan aut NATIONALLICENCE 700 1- Hamasaki Yuko Department of Pediatric Nephrology, Tokyo Metropolitan Children's Medical Center, 2-8-29 Musashidai, 183-8561, Fuchu, Tokyo, Japan aut NATIONALLICENCE 700 1- Sakai Tomoyuki Department of Pediatric Nephrology, Tokyo Metropolitan Children's Medical Center, 2-8-29 Musashidai, 183-8561, Fuchu, Tokyo, Japan aut NATIONALLICENCE 700 1- Hataya Hiroshi Department of Pediatric Nephrology, Tokyo Metropolitan Children's Medical Center, 2-8-29 Musashidai, 183-8561, Fuchu, Tokyo, Japan aut NATIONALLICENCE 700 1- Goto Tomohide Department of Pediatric Neurology, Tokyo Metropolitan Children's Medical Center, Fuchu, Japan aut NATIONALLICENCE 700 1- Miyama Sahoko Department of Pediatric Neurology, Tokyo Metropolitan Children's Medical Center, Fuchu, Japan aut NATIONALLICENCE 700 1- Kono Tatsuo Department of Pediatric Radiology, Tokyo Metropolitan Children's Medical Center, Fuchu, Japan aut NATIONALLICENCE 700 1- Honda Masataka Department of Pediatric Nephrology, Tokyo Metropolitan Children's Medical Center, 2-8-29 Musashidai, 183-8561, Fuchu, Tokyo, Japan aut NATIONALLICENCE 773 0- Clinical and Experimental Nephrology Springer Japan 15/2(2011-04-01), 275-280 1342-1751 15:2<275 2011 15 10157 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer