caa a22 4500 445883863 CHVBK 20180317145553.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s10157-010-0384-y doi (NATIONALLICENCE)springer-10.1007/s10157-010-0384-y Clinical significance of tubular and podocyte biomarkers in acute kidney injury [Elektronische Daten] [Katsuomi Matsui, Atsuko Kamijo-Ikemori, Masanori Hara, Takeshi Sugaya, Takamitsu Kodama, Sigeki Fujitani, Yasuhiko Taira, Takashi Yasuda, Kenjiro Kimura] Background: Acute kidney injury (AKI) is a common complication in critically ill patients. Urinary excretion of liver-type fatty acid-binding protein (L-FABP), which is expressed in the proximal tubules, reflects the presence of tubular injury. Urinary excretion of podocalyxin (PCX), a glycoprotein prominently expressed on podocytes, is associated with podocyte injury. Our aims were to evaluate the utility of urinary L-FABP for the early detection of AKI and to examine whether podocyte injury is present in AKI patients using the biomarker of urinary PCX. Methods: Patients admitted to the intensive care unit (ICU) were divided into the AKI group (n=14) and non-AKI group (n=11), according to the occurrence of AKI during hospitalization in the ICU. Changes in various biomarkers were evaluated. Results: In the AKI group, elevation of urinary L-FABP level [maximum value of L-FABP, 199.0 (92.5-433.6)μg/g creatinine, median (25-75% interquartile range)], which reflects tubular injury (area under the curve 0.95, cut-off value 44.1μg/g Cr), occurred between −30 and 0h before the occurrence of AKI (i.e., the time at which serum creatinine peaked), and elevation of urinary PCX level [maximum value of PCX, 389.5 (267.0-501.0)μg/g creatinine; upper limit of reference value, 160μg/g creatinine] occurred during the time of recovery from AKI when serum creatinine levels were decreasing between 34.0 and 72.0h after the occurrence of AKI. Furthermore, a parameter with the primary large AUC for predicting the onset of AKI was urinary L-FABP. Conclusions: Our study suggests that L-FABP is a useful biomarker for early detection of AKI and that podocyte injury was induced during the recovery phase of AKI. Japanese Society of Nephrology, 2010 Acute kidney injury (AKI) nationallicence Liver-type fatty acid-binding protein (L-FABP) nationallicence Podocalyxin (PCX) nationallicence Podocyte injury nationallicence Matsui Katsuomi Department of Nephrology and Hypertension, Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-Ku, 216-8511, Kawasaki, Kanagawa, Japan aut Kamijo-Ikemori Atsuko Department of Nephrology and Hypertension, Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-Ku, 216-8511, Kawasaki, Kanagawa, Japan aut Hara Masanori Department of Pediatrics, Yoshida Hospital, Niigata, Japan aut Sugaya Takeshi Department of Nephrology and Hypertension, Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-Ku, 216-8511, Kawasaki, Kanagawa, Japan aut Kodama Takamitsu Department of Emergency and Clinical Care Medicine, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan aut Fujitani Sigeki Department of Emergency and Clinical Care Medicine, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan aut Taira Yasuhiko Department of Emergency and Clinical Care Medicine, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan aut Yasuda Takashi Department of Nephrology and Hypertension, Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-Ku, 216-8511, Kawasaki, Kanagawa, Japan aut Kimura Kenjiro Department of Nephrology and Hypertension, Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-Ku, 216-8511, Kawasaki, Kanagawa, Japan aut Clinical and Experimental Nephrology Springer Japan 15/2(2011-04-01), 220-225 1342-1751 15:2<220 2011 15 10157 https://doi.org/10.1007/s10157-010-0384-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10157-010-0384-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Matsui Katsuomi Department of Nephrology and Hypertension, Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-Ku, 216-8511, Kawasaki, Kanagawa, Japan aut NATIONALLICENCE 700 1- Kamijo-Ikemori Atsuko Department of Nephrology and Hypertension, Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-Ku, 216-8511, Kawasaki, Kanagawa, Japan aut NATIONALLICENCE 700 1- Hara Masanori Department of Pediatrics, Yoshida Hospital, Niigata, Japan aut NATIONALLICENCE 700 1- Sugaya Takeshi Department of Nephrology and Hypertension, Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-Ku, 216-8511, Kawasaki, Kanagawa, Japan aut NATIONALLICENCE 700 1- Kodama Takamitsu Department of Emergency and Clinical Care Medicine, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan aut NATIONALLICENCE 700 1- Fujitani Sigeki Department of Emergency and Clinical Care Medicine, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan aut NATIONALLICENCE 700 1- Taira Yasuhiko Department of Emergency and Clinical Care Medicine, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan aut NATIONALLICENCE 700 1- Yasuda Takashi Department of Nephrology and Hypertension, Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-Ku, 216-8511, Kawasaki, Kanagawa, Japan aut NATIONALLICENCE 700 1- Kimura Kenjiro Department of Nephrology and Hypertension, Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-Ku, 216-8511, Kawasaki, Kanagawa, Japan aut NATIONALLICENCE 773 0- Clinical and Experimental Nephrology Springer Japan 15/2(2011-04-01), 220-225 1342-1751 15:2<220 2011 15 10157 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer