caa a22 4500 445884835 CHVBK 20180317145555.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s00011-010-0216-2 doi (NATIONALLICENCE)springer-10.1007/s00011-010-0216-2 Association of the NFKBIA gene polymorphisms with susceptibility to autoimmune and inflammatory diseases: a meta-analysis [Elektronische Daten] [Guo-Long Zhang, Yan-Feng Zou, Xiao-Liang Feng, He-Jian Shi, Xu-Feng Du, Min-Hua Shao, Yong Gu, Qing Zhou] Objective: To quantitatively summarize the association of NFKBIA gene polymorphisms with autoimmune and inflammatory diseases. Methods: We surveyed studies on the association of NFKBIA gene polymorphisms with autoimmune and inflammatory diseases in PubMed. Meta-analysis was performed in a fixed/random effect model. Results: We identified 14 studies using a PubMed search. Meta-analysis was performed for NFKBIA gene polymorphisms at positions 2758 (A/G, 5 studies), −881 (A/G, 3 studies), −826 (C/T, 3 studies), and −297 (C/T, 3 studies). We did not detect associations of NFKBIA gene polymorphisms at positions 2758, −881, −297 with autoimmune and inflammatory diseases. An association of NFKBIA gene −826C/T polymorphism with autoimmune and inflammatory diseases was found (C vs. T: OR=1.81, 95% CI=0.97-3.36, P=0.06; CT+TT vs. CC: OR=2.11, 95% CI=1.07-4.19, P=0.03; TT vs. CC+CT: OR=2.20, 95% CI=0.78-6.21, P=0.06; TT vs. CC: OR=2.87, 95% CI=0.78-10.62, P=0.11; CT vs. CC: OR=2.02, 95% CI=1.22-3.36, P=0.006). Conclusion: This meta-analysis demonstrates that autoimmune and inflammatory diseases are associated with NFKBIA gene −826C/T polymorphism, but not with 2758A/G, −881A/G, and −279C/T. Springer Basel AG, 2010 NFKBIA nationallicence Genetic polymorphisms nationallicence Autoimmune nationallicence Inflammatory diseases nationallicence Meta-analysis nationallicence Zhang Guo-Long Department of Dermatology, Affiliated Wuxi People's Hospital of Nanjing Medical University, 214023, Wuxi, Jiangsu, China aut Zou Yan-Feng Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, 230032, Hefei, Anhui, China aut Feng Xiao-Liang Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, 230032, Hefei, Anhui, China aut Shi He-Jian Department of Dermatology, Affiliated Wuxi People's Hospital of Nanjing Medical University, 214023, Wuxi, Jiangsu, China aut Du Xu-Feng Department of Dermatology, Affiliated Wuxi People's Hospital of Nanjing Medical University, 214023, Wuxi, Jiangsu, China aut Shao Min-Hua Department of Dermatology, Wuxi People's Hospital, 299 Qingyang Road, 214023, Wuxi, Jiangsu, China aut Gu Yong Department of Dermatology, Wuxi People's Hospital, 299 Qingyang Road, 214023, Wuxi, Jiangsu, China aut Zhou Qing Department of Dermatology, Affiliated Wuxi People's Hospital of Nanjing Medical University, 214023, Wuxi, Jiangsu, China aut Inflammation Research SP Birkhäuser Verlag Basel 60/1(2011-01-01), 11-18 1023-3830 60:1<11 2011 60 11 https://doi.org/10.1007/s00011-010-0216-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00011-010-0216-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zhang Guo-Long Department of Dermatology, Affiliated Wuxi People's Hospital of Nanjing Medical University, 214023, Wuxi, Jiangsu, China aut NATIONALLICENCE 700 1- Zou Yan-Feng Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, 230032, Hefei, Anhui, China aut NATIONALLICENCE 700 1- Feng Xiao-Liang Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, 230032, Hefei, Anhui, China aut NATIONALLICENCE 700 1- Shi He-Jian Department of Dermatology, Affiliated Wuxi People's Hospital of Nanjing Medical University, 214023, Wuxi, Jiangsu, China aut NATIONALLICENCE 700 1- Du Xu-Feng Department of Dermatology, Affiliated Wuxi People's Hospital of Nanjing Medical University, 214023, Wuxi, Jiangsu, China aut NATIONALLICENCE 700 1- Shao Min-Hua Department of Dermatology, Wuxi People's Hospital, 299 Qingyang Road, 214023, Wuxi, Jiangsu, China aut NATIONALLICENCE 700 1- Gu Yong Department of Dermatology, Wuxi People's Hospital, 299 Qingyang Road, 214023, Wuxi, Jiangsu, China aut NATIONALLICENCE 700 1- Zhou Qing Department of Dermatology, Affiliated Wuxi People's Hospital of Nanjing Medical University, 214023, Wuxi, Jiangsu, China aut NATIONALLICENCE 773 0- Inflammation Research SP Birkhäuser Verlag Basel 60/1(2011-01-01), 11-18 1023-3830 60:1<11 2011 60 11 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer