caa a22 4500 445884843 CHVBK 20180317145555.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s00011-010-0269-2 doi (NATIONALLICENCE)springer-10.1007/s00011-010-0269-2 Ganellin C. Department of Chemistry, University College London, Christopher Ingold Laboratories, 20 Gordon Street, WC1H 0AJ, London, UK aut Personal reflections on Sir James Black (1924-2010) and histamine [Elektronische Daten] [C. Ganellin] Sir James Black, Nobel laureate (1988), became interested in the role of histamine in gastric acid secretion in the early 1950s. In 1964, he joined the pharmaceutical company Smith Kline and French Laboratories at their English subsidiary to seek a new type of antagonist that would block those actions of histamine that were not blocked by mepyramine. No such compound was known and working with medicinal chemists it took four years to discover a lead compound. Further work provided the compound burimamide, which was used to define histamine H2 receptors in 1972 for the first time, and to verify the action in human volunteers. Subsequent work led to the drug metiamide, which was withdrawn during early clinical trials. This was replaced by cimetidine, which was launched in 1977, as the first histamine H2-receptor antagonist and which revolutionized the treatment of peptic ulcer disease. The characterisation of a second type of histamine receptor revitalised interest in histamine and led to many later studies on the role of histamine in inflammation. Springer Basel AG, 2010 Histamine nationallicence Anti-histamine nationallicence GI drugs nationallicence Inflammation Research SP Birkhäuser Verlag Basel 60/1(2011-01-01), 103-110 1023-3830 60:1<103 2011 60 11 https://doi.org/10.1007/s00011-010-0269-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00011-010-0269-2 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Ganellin C. Department of Chemistry, University College London, Christopher Ingold Laboratories, 20 Gordon Street, WC1H 0AJ, London, UK aut NATIONALLICENCE 773 0- Inflammation Research SP Birkhäuser Verlag Basel 60/1(2011-01-01), 103-110 1023-3830 60:1<103 2011 60 11 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer