caa a22 4500 445884851 CHVBK 20180317145555.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s00011-010-0231-3 doi (NATIONALLICENCE)springer-10.1007/s00011-010-0231-3 The effects of lazaroid U-74389G in a rat sepsis model [Elektronische Daten] [Yun-Te Chang, Shue-Ren Wann, Kai-Hseng Hsieh, Yung-Ching Liu, Ching-Hsiung Chang, Mu-Shun Huang, Chun-I Huang, Hong-Tai Chang] Objective and design: To examine the protective effects of a lazaroid, 21-aminosteroid U-74389G, in a rat septic shock model. Materials or subjects: Male Sprague-Dawley rats (n=60) aged 6-8months. Treatment: Groups were exposed to 500cGy radiation followed by E. coli inoculation, and either placebo or lazaroid injection (10mg/kg intraperitoneal) 5days after irradiation. Methods: Hemodynamic measurements, arterial blood gases, serum lactate, total antioxidative capacity, and cytokine levels were measured at specific time intervals. Results: Treatment with the lazaroid U-74389G maintained cardiac output and mean aortic pressure. Lazaroid treatment also prevented the increase in serum lactate seen in placebo-treated rats. Cytokine serum levels in lazaroid-treated rats were not significantly different from those in placebo-treated rats at any time point. Conclusions: Lazaroid treatment of E. coli-inoculated septic animals lessens the hemodynamic deterioration seen in sepsis. Springer Basel AG, 2010 Septic shock nationallicence Cardiac output nationallicence Lactate nationallicence Cytokines nationallicence E. coli nationallicence Chang Yun-Te Department of Emergency Medicine, Kaohsiung Veterans General Hospital, 386, Ta-Chung 1st Road, Kaohsiung City, Taiwan aut Wann Shue-Ren Department of Emergency Medicine, Kaohsiung Veterans General Hospital, 386, Ta-Chung 1st Road, Kaohsiung City, Taiwan aut Hsieh Kai-Hseng Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan aut Liu Yung-Ching The Infectious Diseases Section, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan aut Chang Ching-Hsiung Department of Radiation Oncology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan aut Huang Mu-Shun School of Medicine, National Yang-Ming University, Taipei, Taiwan aut Huang Chun-I School of Medicine, National Yang-Ming University, Taipei, Taiwan aut Chang Hong-Tai Department of Emergency Medicine, Kaohsiung Veterans General Hospital, 386, Ta-Chung 1st Road, Kaohsiung City, Taiwan aut Inflammation Research SP Birkhäuser Verlag Basel 60/1(2011-01-01), 29-35 1023-3830 60:1<29 2011 60 11 https://doi.org/10.1007/s00011-010-0231-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00011-010-0231-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chang Yun-Te Department of Emergency Medicine, Kaohsiung Veterans General Hospital, 386, Ta-Chung 1st Road, Kaohsiung City, Taiwan aut NATIONALLICENCE 700 1- Wann Shue-Ren Department of Emergency Medicine, Kaohsiung Veterans General Hospital, 386, Ta-Chung 1st Road, Kaohsiung City, Taiwan aut NATIONALLICENCE 700 1- Hsieh Kai-Hseng Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan aut NATIONALLICENCE 700 1- Liu Yung-Ching The Infectious Diseases Section, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan aut NATIONALLICENCE 700 1- Chang Ching-Hsiung Department of Radiation Oncology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan aut NATIONALLICENCE 700 1- Huang Mu-Shun School of Medicine, National Yang-Ming University, Taipei, Taiwan aut NATIONALLICENCE 700 1- Huang Chun-I School of Medicine, National Yang-Ming University, Taipei, Taiwan aut NATIONALLICENCE 700 1- Chang Hong-Tai Department of Emergency Medicine, Kaohsiung Veterans General Hospital, 386, Ta-Chung 1st Road, Kaohsiung City, Taiwan aut NATIONALLICENCE 773 0- Inflammation Research SP Birkhäuser Verlag Basel 60/1(2011-01-01), 29-35 1023-3830 60:1<29 2011 60 11 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer