caa a22 4500 445884878 CHVBK 20180317145556.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s00011-010-0240-2 doi (NATIONALLICENCE)springer-10.1007/s00011-010-0240-2 Thromboxane-prostanoid receptor expression and antagonism in dextran-sodium sulfate-induced colitis [Elektronische Daten] [Patsy Carter, Robert McElhatten, Songlin Zhang, William Wright, Norman Harris] Objective: In the current study of murine colitis, the potential roles of thromboxane and the thromboxane-prostanoid (TP) receptor were investigated, in as much as thromboxane signaling has been implicated in human inflammatory bowel disease. Methods: Colitis was induced in C57BL/6 mice via ingestion of dextran sodium sulfate (DSS), with or without co-administration of the thromboxane synthase inhibitor ozagrel (25mg/kg/day) or the TP receptor antagonist vapiprost (2.5mg/kg/day). Results: Immunohistochemistry of colonic tissue demonstrated a DSS-induced increase in TP receptor expression, but not of thromboxane synthase. Moreover, tissue levels of the metabolite thromboxane B2 were unchanged by DSS. Vapiprost, but not ozagrel, partially attenuated histologic signs of inflammation induced by DSS, with vapiprost allowing a smaller increase in colon weight per unit length than ozagrel. Vapiprost also tended to attenuate DSS-induced alterations in intestinal transit. Conclusions: In summary, TP receptor antagonism was more effective than thromboxane synthase inhibition in alleviating DSS-induced colitis in mice. Springer Basel AG, 2010 Colitis nationallicence Thromboxane nationallicence Prostaglandins nationallicence Motility nationallicence Inflammation nationallicence Carter Patsy Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, 1501 Kings Highway, 71130, Shreveport, LA, USA aut McElhatten Robert Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, 1501 Kings Highway, 71130, Shreveport, LA, USA aut Zhang Songlin Department of Pathology, Louisiana State University Health Sciences Center, Shreveport, LA, USA aut Wright William Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, 1501 Kings Highway, 71130, Shreveport, LA, USA aut Harris Norman Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, 1501 Kings Highway, 71130, Shreveport, LA, USA aut Inflammation Research SP Birkhäuser Verlag Basel 60/1(2011-01-01), 87-92 1023-3830 60:1<87 2011 60 11 https://doi.org/10.1007/s00011-010-0240-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00011-010-0240-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Carter Patsy Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, 1501 Kings Highway, 71130, Shreveport, LA, USA aut NATIONALLICENCE 700 1- McElhatten Robert Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, 1501 Kings Highway, 71130, Shreveport, LA, USA aut NATIONALLICENCE 700 1- Zhang Songlin Department of Pathology, Louisiana State University Health Sciences Center, Shreveport, LA, USA aut NATIONALLICENCE 700 1- Wright William Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, 1501 Kings Highway, 71130, Shreveport, LA, USA aut NATIONALLICENCE 700 1- Harris Norman Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, 1501 Kings Highway, 71130, Shreveport, LA, USA aut NATIONALLICENCE 773 0- Inflammation Research SP Birkhäuser Verlag Basel 60/1(2011-01-01), 87-92 1023-3830 60:1<87 2011 60 11 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer