caa a22 4500 445884894 CHVBK 20180317145556.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s00011-010-0236-y doi (NATIONALLICENCE)springer-10.1007/s00011-010-0236-y Serum complement C3 has a stronger association with insulin resistance than high sensitive C-reactive protein in non-diabetic Chinese [Elektronische Daten] [Bangqiong Wang, Qifu Li, Yuanjuan Jiang, Zhoujun Liu, Li Zhong, Rong Luo, Qingfeng Cheng, Hua Qing] Objective: To compare association of complement C3 (C3) and high sensitive C-reactive protein (hs-CRP) with insulin resistance. Subjects: A total of 587 non-diabetic Chinese aged 20-80years were recruited. Methods: Complement C3 and hs-CRP were measured by the rate nephelometry method and the particle enhanced immunoturbidimetric method, respectively, and their relationship to insulin resistance was assessed. Insulin resistance was defined as the upper quartile of HOMA2-IR. Results: Complement C3 and hs-CRP were significantly higher in subjects with insulin resistance than those without. Complement C3 was the second strongest determinant of insulin in the study (β=0.34, P<0.001). By regression analysis, C3 was significantly associated with insulin resistance (OR=3.78, P<0.05), independent of waist circumference and other metabolic risk factors; however, hs-CRP was not. Receiver operating characteristic curve analysis indicated the best model predicting insulin resistance was one that included C3 and waist circumference (AUC=0.741, P<0.05). Conclusion: Compared to hs-CRP, serum C3 might be a better inflammatory marker of insulin resistance in the non-diabetic Chinese population. Springer Basel AG, 2010 Insulin resistance nationallicence C-reactive protein nationallicence Complement C3 nationallicence Wang Bangqiong Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, No.1 Youyi Street, 400016, Chongqing, China aut Li Qifu Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, No.1 Youyi Street, 400016, Chongqing, China aut Jiang Yuanjuan Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, No.1 Youyi Street, 400016, Chongqing, China aut Liu Zhoujun Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, No.1 Youyi Street, 400016, Chongqing, China aut Zhong Li Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, No.1 Youyi Street, 400016, Chongqing, China aut Luo Rong Medical Examination Center, The First Affiliated Hospital of Chongqing Medical University, 400016, Chongqing, China aut Cheng Qingfeng Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, No.1 Youyi Street, 400016, Chongqing, China aut Qing Hua Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, No.1 Youyi Street, 400016, Chongqing, China aut Inflammation Research SP Birkhäuser Verlag Basel 60/1(2011-01-01), 63-68 1023-3830 60:1<63 2011 60 11 https://doi.org/10.1007/s00011-010-0236-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00011-010-0236-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wang Bangqiong Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, No.1 Youyi Street, 400016, Chongqing, China aut NATIONALLICENCE 700 1- Li Qifu Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, No.1 Youyi Street, 400016, Chongqing, China aut NATIONALLICENCE 700 1- Jiang Yuanjuan Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, No.1 Youyi Street, 400016, Chongqing, China aut NATIONALLICENCE 700 1- Liu Zhoujun Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, No.1 Youyi Street, 400016, Chongqing, China aut NATIONALLICENCE 700 1- Zhong Li Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, No.1 Youyi Street, 400016, Chongqing, China aut NATIONALLICENCE 700 1- Luo Rong Medical Examination Center, The First Affiliated Hospital of Chongqing Medical University, 400016, Chongqing, China aut NATIONALLICENCE 700 1- Cheng Qingfeng Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, No.1 Youyi Street, 400016, Chongqing, China aut NATIONALLICENCE 700 1- Qing Hua Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, No.1 Youyi Street, 400016, Chongqing, China aut NATIONALLICENCE 773 0- Inflammation Research SP Birkhäuser Verlag Basel 60/1(2011-01-01), 63-68 1023-3830 60:1<63 2011 60 11 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer