caa a22 4500 445884924 CHVBK 20180317145556.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s00011-010-0246-9 doi (NATIONALLICENCE)springer-10.1007/s00011-010-0246-9 Rőszer Tamás Research Group of Apoptosis and Genomics, Hungarian Academy of Sciences, Debrecen, Hungary aut Inflammation as death or life signal in diabetic fracture healing [Elektronische Daten] [Tamás Rőszer] Increased apoptosis of chondrocytes and osteoblasts and prolonged survival of osteoclasts lead to early destruction of callus tissue and impair bone remodeling in fracture healing of diabetic patients. Diabetes is accompanied by an increased inflammatory state, reactive oxgen species (ROS) generation and accumulation of advanced glycation end products (AGEs), a heterogenous group of toxic metabolites that can induce inflammation. Prolonged hyperglycemia and insulin resistance correlate with increased apoptosis rate and, accordingly, the proapoptotic role of several inflammatory mediators, ROS and AGEs has been also documented. In this review we summarize the most recent reports supporting the idea that inflammatory signaling increases chondrocyte and osteoblast death and prolongs osteoclast survival, resulting in impaired bone regeneration in diabetes. Antagonising inflammatory signal pathways and solution of inflammation may deserve greater attention in the management of diabetic fracture healing. Springer Basel AG, 2010 Diabetes mellitus nationallicence Apoptosis nationallicence Inflammation nationallicence Bone homeostasis nationallicence Regeneration nationallicence Inflammation Research SP Birkhäuser Verlag Basel 60/1(2011-01-01), 3-10 1023-3830 60:1<3 2011 60 11 https://doi.org/10.1007/s00011-010-0246-9 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00011-010-0246-9 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Rőszer Tamás Research Group of Apoptosis and Genomics, Hungarian Academy of Sciences, Debrecen, Hungary aut NATIONALLICENCE 773 0- Inflammation Research SP Birkhäuser Verlag Basel 60/1(2011-01-01), 3-10 1023-3830 60:1<3 2011 60 11 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer