caa a22 4500 445884967 CHVBK 20180317145556.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00011-011-0307-8 doi (NATIONALLICENCE)springer-10.1007/s00011-011-0307-8 Anti-inflammatory effects of ivermectin in mouse model of allergic asthma [Elektronische Daten] [Shuhan Yan, Xinxin Ci, Na Chen, Chi Chen, Xiangchao Li, Xiao Chu, Jianhua Li, Xuming Deng] Background and objective: Asthma is an inflammatory disease of the lungs that is characterised by increased inflammatory cell infiltration into the airways and poor respiratory function. Ivermectin is a semi-synthetic derivative of a family of macrocyclic lactones that shows broad-spectrum anti-parasitic activity. This drug has been shown to possess anti-inflammatory activity, but whether it can be used in asthma treatment has not yet been investigated. In this study, we aimed to investigate the inhibitory effects of ivermectin on allergic asthma symptoms in mice. Methods and results: We used a mouse asthma model, in which allergic airway inflammation and airway remodelling were induced by ovalbumin (OVA) sensitisation and challenge. Ivermectin or PBS treatment was administered 1h before OVA challenge. Ivermectin at 2mg/kg significantly diminished recruitment of immune cells, production of cytokines in the bronchoalveolar lavage fluids and secretion of OVA-specific IgE and IgG1 in the serum. Histological studies indicated that ivermectin suppressed mucus hypersecretion by goblet cells in the airway. Conclusions: This is the first study to demonstrate that ivermectin is an effective suppressor of inflammation and may be efficacious in the treatment of non-infectious airway inflammatory diseases such as allergic asthma. Springer Basel AG, 2011 Allergic airway inflammation nationallicence Asthma nationallicence Ovalbumin-induced mouse model of asthma nationallicence Ivermectin nationallicence BALF : Bronchoalveolar lavage fluids nationallicence Cdyn : Lung compliance nationallicence DEX : Dexamethasone nationallicence H&E : Hematoxylin and eosin nationallicence IVER : Ivermectin nationallicence OVA : Ovalbumin nationallicence PAS : Periodic acid-Schiff nationallicence PBS : Phosphate-buffered saline nationallicence RL : Airway resistance nationallicence Yan Shuhan Department of Veterinary Pharmacology, College of Animal Science and Veterinary Medicine, Jilin University, 130062, Changchun, Jilin, People's Republic of China aut Ci Xinxin Department of Veterinary Pharmacology, College of Animal Science and Veterinary Medicine, Jilin University, 130062, Changchun, Jilin, People's Republic of China aut Chen Na Department of Veterinary Pharmacology, College of Animal Science and Veterinary Medicine, Jilin University, 130062, Changchun, Jilin, People's Republic of China aut Chen Chi Department of Veterinary Pharmacology, College of Animal Science and Veterinary Medicine, Jilin University, 130062, Changchun, Jilin, People's Republic of China aut Li Xiangchao Department of Veterinary Pharmacology, College of Animal Science and Veterinary Medicine, Jilin University, 130062, Changchun, Jilin, People's Republic of China aut Chu Xiao Department of Veterinary Pharmacology, College of Animal Science and Veterinary Medicine, Jilin University, 130062, Changchun, Jilin, People's Republic of China aut Li Jianhua Department of Veterinary Pharmacology, College of Animal Science and Veterinary Medicine, Jilin University, 130062, Changchun, Jilin, People's Republic of China aut Deng Xuming Department of Veterinary Pharmacology, College of Animal Science and Veterinary Medicine, Jilin University, 130062, Changchun, Jilin, People's Republic of China aut Inflammation Research SP Birkhäuser Verlag Basel 60/6(2011-06-01), 589-596 1023-3830 60:6<589 2011 60 11 https://doi.org/10.1007/s00011-011-0307-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00011-011-0307-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yan Shuhan Department of Veterinary Pharmacology, College of Animal Science and Veterinary Medicine, Jilin University, 130062, Changchun, Jilin, People's Republic of China aut NATIONALLICENCE 700 1- Ci Xinxin Department of Veterinary Pharmacology, College of Animal Science and Veterinary Medicine, Jilin University, 130062, Changchun, Jilin, People's Republic of China aut NATIONALLICENCE 700 1- Chen Na Department of Veterinary Pharmacology, College of Animal Science and Veterinary Medicine, Jilin University, 130062, Changchun, Jilin, People's Republic of China aut NATIONALLICENCE 700 1- Chen Chi Department of Veterinary Pharmacology, College of Animal Science and Veterinary Medicine, Jilin University, 130062, Changchun, Jilin, People's Republic of China aut NATIONALLICENCE 700 1- Li Xiangchao Department of Veterinary Pharmacology, College of Animal Science and Veterinary Medicine, Jilin University, 130062, Changchun, Jilin, People's Republic of China aut NATIONALLICENCE 700 1- Chu Xiao Department of Veterinary Pharmacology, College of Animal Science and Veterinary Medicine, Jilin University, 130062, Changchun, Jilin, People's Republic of China aut NATIONALLICENCE 700 1- Li Jianhua Department of Veterinary Pharmacology, College of Animal Science and Veterinary Medicine, Jilin University, 130062, Changchun, Jilin, People's Republic of China aut NATIONALLICENCE 700 1- Deng Xuming Department of Veterinary Pharmacology, College of Animal Science and Veterinary Medicine, Jilin University, 130062, Changchun, Jilin, People's Republic of China aut NATIONALLICENCE 773 0- Inflammation Research SP Birkhäuser Verlag Basel 60/6(2011-06-01), 589-596 1023-3830 60:6<589 2011 60 11 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer