caa a22 4500 445884983 CHVBK 20180317145556.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00011-011-0310-0 doi (NATIONALLICENCE)springer-10.1007/s00011-011-0310-0 Human thymic stromal lymphopoietin enhances expression of CD80 in human CD14+ monocytes/macrophages [Elektronische Daten] [Reiji Hirano, Shunji Hasegawa, Kunio Hashimoto, Yasuhiro Haneda, Ayami Ohsaki, Takashi Ichiyama] Objective: Human thymic stromal lymphopoietin (TSLP), an epithelial cell-derived cytokine, promotes inflammatory T helper type 2 cell (Th2) differentiation of naive CD4+ T cells. TSLP is highly produced in keratinocytes of patients with atopic dermatitis and bronchial epithelia of patients with asthma and was thought to be a master switch for allergic inflammation. We sought to examine the effect of TSLP in human monocytes/macrophages. Methods: The effect of TSLP on the expression of cell surface antigens (CD11c, CD16, CD54, CD80, CD86, and HLA-DR) in peripheral blood CD14+ monocytes/macrophages was examined. Results: TSLP enhanced the expression of CD80 in peripheral blood CD14+ monocytes/macrophages but not that of other cell surface antigens. It was associated with an increased percentage of CD14dim/−, CD80+, CD11c+, and HLA-DR+ cells, which was consistent with the increased differentiation of myeloid dendritic cells. Conclusions: TSLP induces CD80 expression in human peripheral blood CD14+ monocytes/macrophages; this indicates monocyte/macrophage activation. This may be associated with their differentiation into myeloid dendritic cells. Springer Basel AG, 2011 TSLP nationallicence Monocytes/macrophages nationallicence CD80 nationallicence Dendritic cells nationallicence Hirano Reiji Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-kogushi, 755-8505, Ube, Yamaguchi, Japan aut Hasegawa Shunji Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-kogushi, 755-8505, Ube, Yamaguchi, Japan aut Hashimoto Kunio Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-kogushi, 755-8505, Ube, Yamaguchi, Japan aut Haneda Yasuhiro Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-kogushi, 755-8505, Ube, Yamaguchi, Japan aut Ohsaki Ayami Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-kogushi, 755-8505, Ube, Yamaguchi, Japan aut Ichiyama Takashi Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-kogushi, 755-8505, Ube, Yamaguchi, Japan aut Inflammation Research SP Birkhäuser Verlag Basel 60/6(2011-06-01), 605-610 1023-3830 60:6<605 2011 60 11 https://doi.org/10.1007/s00011-011-0310-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00011-011-0310-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hirano Reiji Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-kogushi, 755-8505, Ube, Yamaguchi, Japan aut NATIONALLICENCE 700 1- Hasegawa Shunji Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-kogushi, 755-8505, Ube, Yamaguchi, Japan aut NATIONALLICENCE 700 1- Hashimoto Kunio Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-kogushi, 755-8505, Ube, Yamaguchi, Japan aut NATIONALLICENCE 700 1- Haneda Yasuhiro Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-kogushi, 755-8505, Ube, Yamaguchi, Japan aut NATIONALLICENCE 700 1- Ohsaki Ayami Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-kogushi, 755-8505, Ube, Yamaguchi, Japan aut NATIONALLICENCE 700 1- Ichiyama Takashi Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-kogushi, 755-8505, Ube, Yamaguchi, Japan aut NATIONALLICENCE 773 0- Inflammation Research SP Birkhäuser Verlag Basel 60/6(2011-06-01), 605-610 1023-3830 60:6<605 2011 60 11 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer