caa a22 4500 445885033 CHVBK 20180317145556.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00011-011-0319-4 doi (NATIONALLICENCE)springer-10.1007/s00011-011-0319-4 Inflammatory pattern recognition receptors and their ligands: factors contributing to the pathogenesis of preeclampsia [Elektronische Daten] [Toshiyuki Sado, Katsuhiko Naruse, Taketoshi Noguchi, Shoji Haruta, Shozo Yoshida, Yasuhito Tanase, Takashi Kitanaka, Hidekazu Oi, Hiroshi Kobayashi] Problem: Preeclampsia, a pregnancy-specific hypertensive syndrome, is one of the leading causes of premature births as well as fetal and maternal death. Preeclampsia lacks effective therapies because of the poor understanding of disease pathogenesis. The aim of this paper is to review molecular signaling pathways that could be responsible for the pathogenesis of preeclampsia. Method of study: This article reviews the English-language literature for pathogenesis and pathophysiological mechanisms of preeclampsia based on genome-wide gene expression profiling and proteomic studies. Results: We show that the expression of the genes and proteins involved in response to stress, host-pathogen interactions, immune system, inflammation, lipid metabolism, carbohydrate metabolism, growth and tissue remodeling was increased in preeclampsia. Several significant common pathways observed in preeclampsia overlap the datasets identified in TLR (Toll-like receptor)- and RAGE (receptor for advanced glycation end products)-dependent signaling pathways. Placental oxidative stress and subsequent chronic inflammation are considered to be major contributors to the development of preeclampsia. Conclusion: This review summarizes recent advances in TLR- and RAGE-mediated signaling and the target molecules, and provides new insights into the pathogenesis of preeclampsia. Springer Basel AG, 2011 Inflammation nationallicence Oxidative stress nationallicence Preeclampsia nationallicence RAGE nationallicence TLR nationallicence Sado Toshiyuki Department of Obstetrics and Gynecology, Nara Medical University, 840 Shijo-cho, 634-8522, Kashihara, Nara, Japan aut Naruse Katsuhiko Department of Obstetrics and Gynecology, Nara Medical University, 840 Shijo-cho, 634-8522, Kashihara, Nara, Japan aut Noguchi Taketoshi Department of Obstetrics and Gynecology, Nara Medical University, 840 Shijo-cho, 634-8522, Kashihara, Nara, Japan aut Haruta Shoji Department of Obstetrics and Gynecology, Nara Medical University, 840 Shijo-cho, 634-8522, Kashihara, Nara, Japan aut Yoshida Shozo Department of Obstetrics and Gynecology, Nara Medical University, 840 Shijo-cho, 634-8522, Kashihara, Nara, Japan aut Tanase Yasuhito Department of Obstetrics and Gynecology, Nara Medical University, 840 Shijo-cho, 634-8522, Kashihara, Nara, Japan aut Kitanaka Takashi Department of Obstetrics and Gynecology, Nara Medical University, 840 Shijo-cho, 634-8522, Kashihara, Nara, Japan aut Oi Hidekazu Department of Obstetrics and Gynecology, Nara Medical University, 840 Shijo-cho, 634-8522, Kashihara, Nara, Japan aut Kobayashi Hiroshi Department of Obstetrics and Gynecology, Nara Medical University, 840 Shijo-cho, 634-8522, Kashihara, Nara, Japan aut Inflammation Research SP Birkhäuser Verlag Basel 60/6(2011-06-01), 509-520 1023-3830 60:6<509 2011 60 11 https://doi.org/10.1007/s00011-011-0319-4 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00011-011-0319-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sado Toshiyuki Department of Obstetrics and Gynecology, Nara Medical University, 840 Shijo-cho, 634-8522, Kashihara, Nara, Japan aut NATIONALLICENCE 700 1- Naruse Katsuhiko Department of Obstetrics and Gynecology, Nara Medical University, 840 Shijo-cho, 634-8522, Kashihara, Nara, Japan aut NATIONALLICENCE 700 1- Noguchi Taketoshi Department of Obstetrics and Gynecology, Nara Medical University, 840 Shijo-cho, 634-8522, Kashihara, Nara, Japan aut NATIONALLICENCE 700 1- Haruta Shoji Department of Obstetrics and Gynecology, Nara Medical University, 840 Shijo-cho, 634-8522, Kashihara, Nara, Japan aut NATIONALLICENCE 700 1- Yoshida Shozo Department of Obstetrics and Gynecology, Nara Medical University, 840 Shijo-cho, 634-8522, Kashihara, Nara, Japan aut NATIONALLICENCE 700 1- Tanase Yasuhito Department of Obstetrics and Gynecology, Nara Medical University, 840 Shijo-cho, 634-8522, Kashihara, Nara, Japan aut NATIONALLICENCE 700 1- Kitanaka Takashi Department of Obstetrics and Gynecology, Nara Medical University, 840 Shijo-cho, 634-8522, Kashihara, Nara, Japan aut NATIONALLICENCE 700 1- Oi Hidekazu Department of Obstetrics and Gynecology, Nara Medical University, 840 Shijo-cho, 634-8522, Kashihara, Nara, Japan aut NATIONALLICENCE 700 1- Kobayashi Hiroshi Department of Obstetrics and Gynecology, Nara Medical University, 840 Shijo-cho, 634-8522, Kashihara, Nara, Japan aut NATIONALLICENCE 773 0- Inflammation Research SP Birkhäuser Verlag Basel 60/6(2011-06-01), 509-520 1023-3830 60:6<509 2011 60 11 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer