caa a22 4500 445885041 CHVBK 20180317145556.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00011-010-0303-4 doi (NATIONALLICENCE)springer-10.1007/s00011-010-0303-4 Comparison of cardioprotective and anti-inflammatory effects of ischemia pre- and postconditioning in rats with myocardial ischemia-reperfusion injury [Elektronische Daten] [Jun Xiong, Qiang Wang, Fu-Shan Xue, Yuan-Jing Yuan, Shan Li, Jian-Hua Liu, Xu Liao, Yan-Ming Zhang] Objective: To compare cardioprotective and anti-inflammatory effects of ischemia preconditioning (IPC) and ischemia postconditioning (IPOC) in a rat myocardial ischemia-reperfusion injury (IRI) model. Methods: Forty Sprague-Dawley rats were randomly divided equally into four groups. In the groups other than the sham group, the left anterior descending coronary artery was ligated for 30min followed by a 180min reperfusion in vivo. The control group was subjected to no additional intervention, the IPC group to three cycles of 5min ischemia separated by 5min reperfusion before the index ischemia and the IPOC group to three cycles of 10s ischemia separated by 10s reperfusion immediately after the end of the index ischemia. Hemodynamic changes during the ischemia and reperfusion were recorded. At 180min of reperfusion, serum concentrations of troponin I (TnI), tumor necrosis factor α (TNF-α) and high-mobility group box 1 (HMGB-1) were assayed, and the infarction size was assessed by Evans blue and triphenyltetrazolium chloride staining. Results: Compared to the control group, infarct size and serum concentrations of TnI, TNF-α and HMGB1 at 180min of reperfusion were significantly reduced in the IPC and IPOC groups. However, infarct size and serum concentrations of TNF-α and HMGB1 at 180min of reperfusion were significantly increased in the IPOC group compared to the IPC group. Conclusions: In the rats with myocardial IRI in vivo, both IPC and IPOC can produce significant cardioprotective and anti-inflammatory effects. However, cardioprotective and anti-inflammatory effects provided by IPOC are weaker than with IPC. Springer Basel AG, 2010 Ischemia-reperfusion injury nationallicence Ischemia preconditioning nationallicence Ischemia postconditioning nationallicence Inflammation nationallicence Xiong Jun Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100144, Beijing, China aut Wang Qiang Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100144, Beijing, China aut Xue Fu-Shan Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100144, Beijing, China aut Yuan Yuan-Jing Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100144, Beijing, China aut Li Shan Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100144, Beijing, China aut Liu Jian-Hua Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100144, Beijing, China aut Liao Xu Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100144, Beijing, China aut Zhang Yan-Ming Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100144, Beijing, China aut Inflammation Research SP Birkhäuser Verlag Basel 60/6(2011-06-01), 547-554 1023-3830 60:6<547 2011 60 11 https://doi.org/10.1007/s00011-010-0303-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00011-010-0303-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Xiong Jun Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100144, Beijing, China aut NATIONALLICENCE 700 1- Wang Qiang Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100144, Beijing, China aut NATIONALLICENCE 700 1- Xue Fu-Shan Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100144, Beijing, China aut NATIONALLICENCE 700 1- Yuan Yuan-Jing Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100144, Beijing, China aut NATIONALLICENCE 700 1- Li Shan Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100144, Beijing, China aut NATIONALLICENCE 700 1- Liu Jian-Hua Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100144, Beijing, China aut NATIONALLICENCE 700 1- Liao Xu Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100144, Beijing, China aut NATIONALLICENCE 700 1- Zhang Yan-Ming Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100144, Beijing, China aut NATIONALLICENCE 773 0- Inflammation Research SP Birkhäuser Verlag Basel 60/6(2011-06-01), 547-554 1023-3830 60:6<547 2011 60 11 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer