caa a22 4500 445885211 CHVBK 20180317145557.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s00011-011-0320-y doi (NATIONALLICENCE)springer-10.1007/s00011-011-0320-y Green tea polyphenols avert chronic inflammation-induced myocardial fibrosis of female rats [Elektronische Daten] [Chwan-Li Shen, Christina Samathanam, Owatha Tatum, Suzanne Graham, Christine Tubb, Jay Cao, Dale Dunn, Jia-Sheng Wang] Objective: Green tea proposes anti-inflammatory properties which may attenuate chronic inflammation-induced fibrosis of vessels. This study evaluated whether green tea polyphenols (GTP) can avert fibrosis or vascular disruption along with mechanisms in rats with chronic inflammation. Treatments: Forty 3-month-old female rats were assigned to a 2 (placebo vs. lipopolysaccharide, administration)×2 (no GTP vs. 0.5% GTP in drinking water) factorial design for 12weeks. Methods: Masson's trichrome staining evaluated myocardial fibrosis in coronary vessels and surrounding myocardium. Whole blood specimens were counted for differentials. Spleen tumor necrosis factor-α (TNF-α) mRNA expression was determined by real-time RT-PCR. Data were analyzed by two-way analysis of variance (ANOVA) followed by mean separation procedures. Results: After 12weeks, lipopolysaccharide administration induced myocardial fibrosis in vessels and surrounding myocardium, spleen TNF-α mRNA expression, and leukocytes, while GTP supplementation in drinking water significantly averted such observation. Conclusions: GTP attenuates myocardial fibrosis through a suppression of chronic inflammation and innate immune responses. Springer Basel AG, 2011 Tea nationallicence Dietary supplement nationallicence Inflammation nationallicence Hematology nationallicence Shen Chwan-Li Department of Pathology, Texas Tech University Health Sciences Center, BB 198, 3601 4th street, 79430-9097, Lubbock, TX, USA aut Samathanam Christina Department of Pathology, Texas Tech University Health Sciences Center, BB 198, 3601 4th street, 79430-9097, Lubbock, TX, USA aut Tatum Owatha Molecular Pathology Program, Texas Tech University Health Sciences Center, Lubbock, TX, USA aut Graham Suzanne Department of Pathology, Texas Tech University Health Sciences Center, BB 198, 3601 4th street, 79430-9097, Lubbock, TX, USA aut Tubb Christine Molecular Pathology Program, Texas Tech University Health Sciences Center, Lubbock, TX, USA aut Cao Jay USDA ARS Grand Forks Human Nutrition Research Center, Grand Forks, ND, USA aut Dunn Dale Department of Pathology, Texas Tech University Health Sciences Center, BB 198, 3601 4th street, 79430-9097, Lubbock, TX, USA aut Wang Jia-Sheng Department of Environmental Health Science, University of Georgia, Athens, GA, USA aut Inflammation Research SP Birkhäuser Verlag Basel 60/7(2011-07-01), 665-672 1023-3830 60:7<665 2011 60 11 https://doi.org/10.1007/s00011-011-0320-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00011-011-0320-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shen Chwan-Li Department of Pathology, Texas Tech University Health Sciences Center, BB 198, 3601 4th street, 79430-9097, Lubbock, TX, USA aut NATIONALLICENCE 700 1- Samathanam Christina Department of Pathology, Texas Tech University Health Sciences Center, BB 198, 3601 4th street, 79430-9097, Lubbock, TX, USA aut NATIONALLICENCE 700 1- Tatum Owatha Molecular Pathology Program, Texas Tech University Health Sciences Center, Lubbock, TX, USA aut NATIONALLICENCE 700 1- Graham Suzanne Department of Pathology, Texas Tech University Health Sciences Center, BB 198, 3601 4th street, 79430-9097, Lubbock, TX, USA aut NATIONALLICENCE 700 1- Tubb Christine Molecular Pathology Program, Texas Tech University Health Sciences Center, Lubbock, TX, USA aut NATIONALLICENCE 700 1- Cao Jay USDA ARS Grand Forks Human Nutrition Research Center, Grand Forks, ND, USA aut NATIONALLICENCE 700 1- Dunn Dale Department of Pathology, Texas Tech University Health Sciences Center, BB 198, 3601 4th street, 79430-9097, Lubbock, TX, USA aut NATIONALLICENCE 700 1- Wang Jia-Sheng Department of Environmental Health Science, University of Georgia, Athens, GA, USA aut NATIONALLICENCE 773 0- Inflammation Research SP Birkhäuser Verlag Basel 60/7(2011-07-01), 665-672 1023-3830 60:7<665 2011 60 11 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer