caa a22 4500 445885254 CHVBK 20180317145557.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s00011-011-0312-y doi (NATIONALLICENCE)springer-10.1007/s00011-011-0312-y Expression of VLA-4 molecule in PBMC from patients with hemorrhagic fever with renal syndrome [Elektronische Daten] [Ming Xie, Yanying Dong, Linjing He, Huixun Ren, Yuqiang Ji, Shemin Lv] Objective and design: The very late antigen-4 (VLA-4) bound to vascular cell adhesion molecule-1 could provide co-stimulatory signals for the activation of T lymphocytes, and these adhesion molecules play key roles in leukocyte adherence and propagation of inflammatory responses. We examined the levels of VLA-4 in the peripheral blood mononuclear cells (PBMC) of patients with hemorrhagic fever with renal syndrome (HFRS). Materials and methods: The levels of VLA-4 in PBMC samples collected from 53 patients by immunohistochemical staining were detected. Results: The expression of VLA-4 in PBMC of HFRS patients at different stages were significantly higher than those in normal controls (P<0.05), except recovery stage (P>0.05). The expression of VLA-4 in PBMC of HFRS patients at different types were significantly higher than those in healthy controls (P<0.05). The levels of VLA-4 in patients with HFRS were positively correlated with serum levels of blood urea nitrogen (BUN) and creatinine (Cr). Conclusions: VLA-4 might play an important role in the immunopathological lesions of HFRS. We found that VLA-4 levels were closely correlated to the severity of the HFRS and the degree of kidney damage. Springer Basel AG, 2011 HFRS nationallicence VLA-4 nationallicence Immunohistochemical staining nationallicence Xie Ming Department of Pathogenic Microbiology and Immunology, Medical School of Xi'an Jiaotong University, 710061, Xi'an, China aut Dong Yanying Department of Pathogenic Microbiology and Immunology, Medical School of Xi'an Jiaotong University, 710061, Xi'an, China aut He Linjing Department of Pathogenic Microbiology and Immunology, Medical School of Xi'an Jiaotong University, 710061, Xi'an, China aut Ren Huixun Department of Pathogenic Microbiology and Immunology, Medical School of Xi'an Jiaotong University, 710061, Xi'an, China aut Ji Yuqiang Department of Pathogenic Microbiology and Immunology, Medical School of Xi'an Jiaotong University, 710061, Xi'an, China aut Lv Shemin Department of Pathogenic Microbiology and Immunology, Medical School of Xi'an Jiaotong University, 710061, Xi'an, China aut Inflammation Research SP Birkhäuser Verlag Basel 60/7(2011-07-01), 613-617 1023-3830 60:7<613 2011 60 11 https://doi.org/10.1007/s00011-011-0312-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00011-011-0312-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Xie Ming Department of Pathogenic Microbiology and Immunology, Medical School of Xi'an Jiaotong University, 710061, Xi'an, China aut NATIONALLICENCE 700 1- Dong Yanying Department of Pathogenic Microbiology and Immunology, Medical School of Xi'an Jiaotong University, 710061, Xi'an, China aut NATIONALLICENCE 700 1- He Linjing Department of Pathogenic Microbiology and Immunology, Medical School of Xi'an Jiaotong University, 710061, Xi'an, China aut NATIONALLICENCE 700 1- Ren Huixun Department of Pathogenic Microbiology and Immunology, Medical School of Xi'an Jiaotong University, 710061, Xi'an, China aut NATIONALLICENCE 700 1- Ji Yuqiang Department of Pathogenic Microbiology and Immunology, Medical School of Xi'an Jiaotong University, 710061, Xi'an, China aut NATIONALLICENCE 700 1- Lv Shemin Department of Pathogenic Microbiology and Immunology, Medical School of Xi'an Jiaotong University, 710061, Xi'an, China aut NATIONALLICENCE 773 0- Inflammation Research SP Birkhäuser Verlag Basel 60/7(2011-07-01), 613-617 1023-3830 60:7<613 2011 60 11 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer