caa a22 4500 445885300 CHVBK 20180317145557.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s00011-011-0372-z doi (NATIONALLICENCE)springer-10.1007/s00011-011-0372-z Association of tumor necrosis factor-α ( TNF - α ) promoter polymorphisms with overweight/obesity in a Korean population [Elektronische Daten] [Gyeong-Im Yu, Eunyoung Ha, Sung-Hee Park, Jae-Hyung Park, Hyun-Sook Jang, Jae-Hoon Bae, In-Sung Chung, Dong-Hoon Shin, Dae-Kyu Song] Objective: Obesity is characterized by the activation of an inflammatory process leading to an increase in proinflammatory cytokines and adipokines. This study was designed to investigate the genetic association between tumor necrosis factor-α (TNF-α) polymorphisms and the risk of obesity in the Korean population. Methods: Three single nucleotide polymorphisms [G-238A (rs361525), C-857T (rs1799724), and C-863A (rs1800630)] in the promoter region of TNF-α gene were analyzed in 123 control [body mass index (BMI) between 18 and 23] and 208 overweight/obese (BMI≥23) subjects. Results: The mean values of BMI in the control and overweight/obese groups were 21.1±1.4 and 25.4±1.8, respectively. Of the three SNPs, G-238A presented a significant association with overweight/obesity in the codominant model; the frequency of the G/G genotype in the overweight/obese group was 9.3% higher than that in the control group (P=0.0046). When control and overweight/obesity subjects were combined together and analyzed, the level of high-density lipoprotein (HDL) was significantly higher in the C-857T C/C type SNP (P<0.05). Conclusions: The results of this study suggest that the G allele of G-238A in TNF-α gene may be a risk factor for overweight/obesity in the Korean population and that the C allele of C-857T may be an protective factor in relation to the HDL level in the general Korean population. Springer Basel AG, 2011 Body mass index nationallicence Tumor necrosis factor nationallicence Obesity/overweight nationallicence Polymorphism nationallicence Yu Gyeong-Im Department of Preventive Medicine, School of Medicine, Institute for Medical Genetics, Keimyung University, 2800 Dalgubeoldaero, Dalseo-Gu, Daegu, Korea aut Ha Eunyoung Department of Biochemistry, School of Medicine, Institute for Medical Genetics, Keimyung University, 2800 Dalgubeoldaero, Dalseo-Gu, Daegu, Korea aut Park Sung-Hee Department of Physiology, School of Medicine, Chronic Disease Research Center, Keimyung University, 2800 Dalgubeoldaero, Dalseo-Gu, Daegu, Korea aut Park Jae-Hyung Department of Physiology, School of Medicine, Chronic Disease Research Center, Keimyung University, 2800 Dalgubeoldaero, Dalseo-Gu, Daegu, Korea aut Jang Hyun-Sook Department of Home Economics Education, Kyungpook National University, Daegu, Korea aut Bae Jae-Hoon Department of Physiology, School of Medicine, Institute for Medical Science, Keimyung University, 2800 Dalgubeoldaero, Dalseo-Gu, Daegu, Korea aut Chung In-Sung Department of Preventive Medicine, School of Medicine, Institute for Medical Genetics, Keimyung University, 2800 Dalgubeoldaero, Dalseo-Gu, Daegu, Korea aut Shin Dong-Hoon Department of Preventive Medicine, School of Medicine, Institute for Medical Genetics, Keimyung University, 2800 Dalgubeoldaero, Dalseo-Gu, Daegu, Korea aut Song Dae-Kyu Department of Physiology, School of Medicine, Chronic Disease Research Center, Keimyung University, 2800 Dalgubeoldaero, Dalseo-Gu, Daegu, Korea aut Inflammation Research SP Birkhäuser Verlag Basel 60/12(2011-12-01), 1099-1105 1023-3830 60:12<1099 2011 60 11 https://doi.org/10.1007/s00011-011-0372-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00011-011-0372-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yu Gyeong-Im Department of Preventive Medicine, School of Medicine, Institute for Medical Genetics, Keimyung University, 2800 Dalgubeoldaero, Dalseo-Gu, Daegu, Korea aut NATIONALLICENCE 700 1- Ha Eunyoung Department of Biochemistry, School of Medicine, Institute for Medical Genetics, Keimyung University, 2800 Dalgubeoldaero, Dalseo-Gu, Daegu, Korea aut NATIONALLICENCE 700 1- Park Sung-Hee Department of Physiology, School of Medicine, Chronic Disease Research Center, Keimyung University, 2800 Dalgubeoldaero, Dalseo-Gu, Daegu, Korea aut NATIONALLICENCE 700 1- Park Jae-Hyung Department of Physiology, School of Medicine, Chronic Disease Research Center, Keimyung University, 2800 Dalgubeoldaero, Dalseo-Gu, Daegu, Korea aut NATIONALLICENCE 700 1- Jang Hyun-Sook Department of Home Economics Education, Kyungpook National University, Daegu, Korea aut NATIONALLICENCE 700 1- Bae Jae-Hoon Department of Physiology, School of Medicine, Institute for Medical Science, Keimyung University, 2800 Dalgubeoldaero, Dalseo-Gu, Daegu, Korea aut NATIONALLICENCE 700 1- Chung In-Sung Department of Preventive Medicine, School of Medicine, Institute for Medical Genetics, Keimyung University, 2800 Dalgubeoldaero, Dalseo-Gu, Daegu, Korea aut NATIONALLICENCE 700 1- Shin Dong-Hoon Department of Preventive Medicine, School of Medicine, Institute for Medical Genetics, Keimyung University, 2800 Dalgubeoldaero, Dalseo-Gu, Daegu, Korea aut NATIONALLICENCE 700 1- Song Dae-Kyu Department of Physiology, School of Medicine, Chronic Disease Research Center, Keimyung University, 2800 Dalgubeoldaero, Dalseo-Gu, Daegu, Korea aut NATIONALLICENCE 773 0- Inflammation Research SP Birkhäuser Verlag Basel 60/12(2011-12-01), 1099-1105 1023-3830 60:12<1099 2011 60 11 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer