caa a22 4500 445885343 CHVBK 20180317145557.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s00011-011-0373-y doi (NATIONALLICENCE)springer-10.1007/s00011-011-0373-y Church Martin Department of Dermatology and Allergy, Allergy Centre Charité, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany aut Comparative inhibition by bilastine and cetirizine of histamine-induced wheal and flare responses in humans [Elektronische Daten] [Martin Church] Objective and design: Comparison of bilastine and cetirizine in inhibiting skin wheal and flare responses over 24h. Subjects: Twenty-one healthy male volunteers (aged 19-44years). Treatment and methods: Volunteers were randomised to receive single oral doses of 20 or 50mg bilastine, 10mg cetirizine or placebo before provocation of wheal and flare responses to 100mg/ml histamine by skin prick 1.5, 4, 8, 12 and 24h later. Results: There were no significant differences between overall inhibitions of wheal or flare by 20mg bilastine and 10mg cetirizine. Bilastine was faster in onset than cetirizine, inhibitions of wheal and flare at 1.5h being 89±3 versus 44±14% (P=0.011) and 85±4 versus 45±14% (P=0.016), respectively (Student's t test). At 1.5h, both wheals and flares were inhibited by >70% in 11/12 volunteers taking bilastine and 3/11 taking cetirizine (P=0.003, Fisher's exact test). There were no significant differences between the drugs at later times. Bilastine 50mg had a longer duration of action than bilastine 20mg. Conclusions: Both 20mg bilastine and 10mg cetirizine are effective and of long duration in reducing histamine-induced wheal and flare responses, the major difference between the two drugs being the more rapid onset of action of bilastine. Springer Basel AG, 2011 Bilastine nationallicence Cetirizine nationallicence Wheal and flare nationallicence Inflammation Research SP Birkhäuser Verlag Basel 60/12(2011-12-01), 1107-1112 1023-3830 60:12<1107 2011 60 11 https://doi.org/10.1007/s00011-011-0373-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00011-011-0373-y text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Church Martin Department of Dermatology and Allergy, Allergy Centre Charité, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany aut NATIONALLICENCE 773 0- Inflammation Research SP Birkhäuser Verlag Basel 60/12(2011-12-01), 1107-1112 1023-3830 60:12<1107 2011 60 11 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer