caa a22 4500 445885408 CHVBK 20180317145557.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00011-010-0266-5 doi (NATIONALLICENCE)springer-10.1007/s00011-010-0266-5 The influence of statin treatment on the inflammatory biomarkers YKL-40 and HsCRP in patients with stable coronary artery disease [Elektronische Daten] [Naja Mygind, Marina Harutyunyan, Anders Mathiasen, Rasmus Ripa, Jens Thune, Jens Gøtze, Julia Johansen, Jens Kastrup] Objective: The inflammatory biomarker YKL-40 is elevated and associated with mortality in patients with stable coronary artery disease (CAD). The aim was to investigate the influence of statin treatment and lipid status on serum YKL-40 and Hs-CRP in patients with stable CAD. Design: Serum YKL-40, HsCRP, total cholesterol, HDL-c, LDL-c and triglycerides levels were measured in 404 statin treated and in 404 matched non-statin treated patients with stable CAD. Results: YKL-40 was significantly higher in non-statin treated 110µg/l (median) compared with 65µg/l in statin treated (p<0.001). HsCRP was 3.3mg/l in non-statin treated compared with 2.1mg/l in statin treated (p<0.001). YKL-40 was not related to cholesterol levels for either statin or non-statin treated patients in the univariate analysis. In statin treated patients, HsCRP was related to a high level of total-cholesterol (p=0.01) and a low level of HDL-c (p<0.001). Conclusions: HsCRP, but not YKL-40, is associated with the cholesterol levels in statin treated patients. This indicates that YKL-40 could be a superior prognostic biomarker in patients with stable CAD, since it is independent of changes in cholesterol levels in both statin and non-statin treated patients. Springer Basel AG, 2010 Coronary artery disease nationallicence Inflammation nationallicence Biomarkers nationallicence Statin treatment nationallicence YKL-40 nationallicence HsCRP nationallicence Mygind Naja Cardiac Catheterization Laboratory 2014, Department of Medicine B, Faculty of Health Sciences, The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark aut Harutyunyan Marina Cardiac Catheterization Laboratory 2014, Department of Medicine B, Faculty of Health Sciences, The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark aut Mathiasen Anders Cardiac Catheterization Laboratory 2014, Department of Medicine B, Faculty of Health Sciences, The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark aut Ripa Rasmus Department of Clinical Physiology and Nuclear Medicine, Frederiksberg Hospital, Frederiksberg, Denmark aut Thune Jens Cardiac Catheterization Laboratory 2014, Department of Medicine B, Faculty of Health Sciences, The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark aut Gøtze Jens Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark aut Johansen Julia Department of Medicine, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark aut Kastrup Jens Cardiac Catheterization Laboratory 2014, Department of Medicine B, Faculty of Health Sciences, The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark aut Inflammation Research SP Birkhäuser Verlag Basel 60/3(2011-03-01), 281-287 1023-3830 60:3<281 2011 60 11 https://doi.org/10.1007/s00011-010-0266-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00011-010-0266-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mygind Naja Cardiac Catheterization Laboratory 2014, Department of Medicine B, Faculty of Health Sciences, The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark aut NATIONALLICENCE 700 1- Harutyunyan Marina Cardiac Catheterization Laboratory 2014, Department of Medicine B, Faculty of Health Sciences, The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark aut NATIONALLICENCE 700 1- Mathiasen Anders Cardiac Catheterization Laboratory 2014, Department of Medicine B, Faculty of Health Sciences, The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark aut NATIONALLICENCE 700 1- Ripa Rasmus Department of Clinical Physiology and Nuclear Medicine, Frederiksberg Hospital, Frederiksberg, Denmark aut NATIONALLICENCE 700 1- Thune Jens Cardiac Catheterization Laboratory 2014, Department of Medicine B, Faculty of Health Sciences, The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark aut NATIONALLICENCE 700 1- Gøtze Jens Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark aut NATIONALLICENCE 700 1- Johansen Julia Department of Medicine, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark aut NATIONALLICENCE 700 1- Kastrup Jens Cardiac Catheterization Laboratory 2014, Department of Medicine B, Faculty of Health Sciences, The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark aut NATIONALLICENCE 773 0- Inflammation Research SP Birkhäuser Verlag Basel 60/3(2011-03-01), 281-287 1023-3830 60:3<281 2011 60 11 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer