caa a22 4500 445885467 CHVBK 20180317145558.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00011-010-0285-2 doi (NATIONALLICENCE)springer-10.1007/s00011-010-0285-2 Inflammatory single nucleotide polymorphisms and the risk of atrial fibrillation: a case control study [Elektronische Daten] [Kristoffer Henningsen, Morten Olesen, Lasse Ravn, Ulrik Dixen, Stig Haunsoe, Helle Bruunsgaard, Jesper Svendsen] Introduction: Systemic inflammation is associated with atrial fibrillation (AF) and inflammatory processes are involved in the pathophysiology of AF. We hypothesized that genetic polymorphisms, which determine the rate of inflammatory cytokines, are associated with increased risk of AF. Materials and methods: We included 158 patients with AF and 188 healthy controls. All patients were genotyped for common single nucleotide polymorphisms (SNPs) in selected inflammatory genes. Results: A case-control analysis of the investigated SNPs (IL1A-889, TNF-308, IL1B-511, IL10-592, IL10-1082, IL18-137 and IL18-607) revealed no significant differences in the frequencies of genotypes between the AF patients and the healthy controls. Springer Basel AG, 2010 Cardiology nationallicence Gene expression nationallicence Henningsen Kristoffer Department of Cardiology, The Heart Centre, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark aut Olesen Morten Department of Cardiology, The Heart Centre, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark aut Ravn Lasse Department of Cardiology, The Heart Centre, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark aut Dixen Ulrik Department of Cardiology, Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark aut Haunsoe Stig Department of Cardiology, The Heart Centre, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark aut Bruunsgaard Helle The Centre of Inflammation and Metabolism, Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark aut Svendsen Jesper Department of Cardiology, The Heart Centre, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark aut Inflammation Research SP Birkhäuser Verlag Basel 60/3(2011-03-01), 209-211 1023-3830 60:3<209 2011 60 11 https://doi.org/10.1007/s00011-010-0285-2 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00011-010-0285-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Henningsen Kristoffer Department of Cardiology, The Heart Centre, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark aut NATIONALLICENCE 700 1- Olesen Morten Department of Cardiology, The Heart Centre, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark aut NATIONALLICENCE 700 1- Ravn Lasse Department of Cardiology, The Heart Centre, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark aut NATIONALLICENCE 700 1- Dixen Ulrik Department of Cardiology, Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark aut NATIONALLICENCE 700 1- Haunsoe Stig Department of Cardiology, The Heart Centre, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark aut NATIONALLICENCE 700 1- Bruunsgaard Helle The Centre of Inflammation and Metabolism, Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark aut NATIONALLICENCE 700 1- Svendsen Jesper Department of Cardiology, The Heart Centre, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark aut NATIONALLICENCE 773 0- Inflammation Research SP Birkhäuser Verlag Basel 60/3(2011-03-01), 209-211 1023-3830 60:3<209 2011 60 11 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer