caa a22 4500 445885580 CHVBK 20180317145558.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00011-011-0357-y doi (NATIONALLICENCE)springer-10.1007/s00011-011-0357-y Genome-wide gene expression study indicates the anti-inflammatory effect of polarized light in recurrent childhood respiratory disease [Elektronische Daten] [A. Falus, M. Fenyő, K. Éder, A. Madarasi] Objectives: The clinical and molecular effects of whole-body polarized light treatment on children suffering from recurrent respiratory infection were studied. Methods: The incidence and duration of respiratory symptoms as well as the length of appropriate antibiotic therapy were measured. Simultaneously, the genome-wide gene expression pattern was examined by whole genome cDNA microarray in peripheral lymphocytes of children. Results: Twenty of 25 children showed a marked clinical improvement, while in five of 25 had poor response or no changes. The gene expression pattern of the patients' peripheral lymphocytes was compared in favorable and poor responders. The lymphocytes of the children with a documented improved clinical response to polarized light therapy showed a decrease in the expression of chemokine genes, such as CXCL1, CXCL2, CXCL3, and IL-8, and in that of the TNFα gene. On the contrary, a rapid elevation was found in the expression of the gene encoding for CYP4F2, a leukotriene B4-metabolizing enzyme. In children with poor clinical response to polarized light therapy, no similar changes were detected in the gene expression pattern of the lymphocytes. Conclusions: The improved clinical symptoms and modified gene expression profile of lymphocytes reveals an anti-inflammatory effect of whole-body polarized light irradiation. Springer Basel AG, 2011 Inflammation nationallicence Respiratory symptoms nationallicence Polarized light nationallicence Gene expression nationallicence Chemokine nationallicence Leukotriene B4 nationallicence Falus A. Department of Genetics, Cell- and Immunobiology, Semmelweis University, Nagyvárad tér 4, 1089, Budapest, Hungary aut Fenyő M. Polárium Ltd, Budapest, Hungary aut Éder K. Department of Genetics, Cell- and Immunobiology, Semmelweis University, Nagyvárad tér 4, 1089, Budapest, Hungary aut Madarasi A. Szt. János Hospital, Budapest, Hungary aut Inflammation Research SP Birkhäuser Verlag Basel 60/10(2011-10-01), 965-972 1023-3830 60:10<965 2011 60 11 https://doi.org/10.1007/s00011-011-0357-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00011-011-0357-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Falus A. Department of Genetics, Cell- and Immunobiology, Semmelweis University, Nagyvárad tér 4, 1089, Budapest, Hungary aut NATIONALLICENCE 700 1- Fenyő M. Polárium Ltd, Budapest, Hungary aut NATIONALLICENCE 700 1- Éder K. Department of Genetics, Cell- and Immunobiology, Semmelweis University, Nagyvárad tér 4, 1089, Budapest, Hungary aut NATIONALLICENCE 700 1- Madarasi A. Szt. János Hospital, Budapest, Hungary aut NATIONALLICENCE 773 0- Inflammation Research SP Birkhäuser Verlag Basel 60/10(2011-10-01), 965-972 1023-3830 60:10<965 2011 60 11 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer