caa a22 4500 445885688 CHVBK 20180317145558.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00011-010-0284-3 doi (NATIONALLICENCE)springer-10.1007/s00011-010-0284-3 Chemokine (CCR) and fractalkine (CX3CR) receptors and end stage renal disease [Elektronische Daten] [Minal Borkar, Gaurav Tripathi, Raj Sharma, Satya Sankhwar, Suraksha Agrawal] Objective and design: Genetic polymorphisms of chemokines and their receptors were reported to be independent risk factors for inflammation associated disease. We explored the role of CCR5-Δ32, CCR5-G59029A, CX3CR1 V249I and T280M gene polymorphisms as susceptibility for end stage renal disease (ESRD). Subjects and methods: We genotyped 258 ESRD and 569 healthy controls by sequence-specific primers and RFLP and examined their association. Results: There was significant difference in genotype frequencies of CCR5-G59029A (p=0.005), and CX3CR1 V249I (p<0.0001) between ESRD and controls. No homozygous individuals were observed for CCR5-Δ32. The haplotype analysis of all four studied genes reveled that haplotype +/A/T/I was more significant in patients and associated with higher risk (OR=2.95) of ESRD. Further, the haplotype of CX3CR1 (T280M, V249I) gene showed 3.6-fold higher in an individual carrying T/I haplotype. No risk was seen for CCR5 haplotypes. Conclusions: These results highlight the role of CCR5 and CX3CR1 in ESRD. Springer Basel AG, 2010 ESRD nationallicence Chemokine receptors nationallicence CCR nationallicence Single nucleotide polymorphisms (SNPs) nationallicence Borkar Minal Department of Medical Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, 226014, Lucknow, UP, India aut Tripathi Gaurav Department of Urology, Chatrapati Sahuji Maharaj Medical University, Lucknow, India aut Sharma Raj Department of Nephrology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India aut Sankhwar Satya Department of Urology, Chatrapati Sahuji Maharaj Medical University, Lucknow, India aut Agrawal Suraksha Department of Medical Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, 226014, Lucknow, UP, India aut Inflammation Research SP Birkhäuser Verlag Basel 60/4(2011-04-01), 399-407 1023-3830 60:4<399 2011 60 11 https://doi.org/10.1007/s00011-010-0284-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00011-010-0284-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Borkar Minal Department of Medical Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, 226014, Lucknow, UP, India aut NATIONALLICENCE 700 1- Tripathi Gaurav Department of Urology, Chatrapati Sahuji Maharaj Medical University, Lucknow, India aut NATIONALLICENCE 700 1- Sharma Raj Department of Nephrology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India aut NATIONALLICENCE 700 1- Sankhwar Satya Department of Urology, Chatrapati Sahuji Maharaj Medical University, Lucknow, India aut NATIONALLICENCE 700 1- Agrawal Suraksha Department of Medical Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, 226014, Lucknow, UP, India aut NATIONALLICENCE 773 0- Inflammation Research SP Birkhäuser Verlag Basel 60/4(2011-04-01), 399-407 1023-3830 60:4<399 2011 60 11 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer