caa a22 4500 445885742 CHVBK 20180317145559.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00011-010-0271-8 doi (NATIONALLICENCE)springer-10.1007/s00011-010-0271-8 Angiogenesis in chronic rhinosinusitis with nasal polyps and in antrochoanal polyps [Elektronische Daten] [Nir Hirshoren, Tzahi Neuman, Menachem Gross, Ron Eliashar] Objectives and study design: Angiogenesis may be related to the pathogenesis and prognosis of chronic rhinosinusitis with nasal polyposis. This cross-sectional study, in a tertiary university hospital, evaluates angiogenesis parameters in nasal polyps, antrochoanal polyps and middle turbinates. Subjects: Nasal polyps obtained from 24 consecutive patients, were compared to 10 normal middle turbinates and to 11 antrochoanal polyps. Methods: Analyzing for the expression of the angiogenic marker CD34 by immunohistochemistry. Blood vessels count, vascular surface density and microvessel density were measured by manual and computerized methods. Results: Angiogenesis was significantly higher in nasal polyps compared to control turbinates and to antrochoanal polyps (p=0.0001 and p=0.007, respectively). Antrochoanal polyps showed significantly more angiogenesis than normal middle turbinates (p=0.001). Angiogenesis was not elevated in sub-groups of nasal polyposis patients considered to have worse prognosis. Conclusions: Angiogenesis probably plays a role in the pathogenesis of both nasal polyposis and antrochoanal polyps. However, the significantly higher angiogenesis found in nasal polyps compared to antrochoanal polyps may support a different mechanism of growth. The lack of difference between angiogenesis and nasal polyposis patients sub-groups, may imply that angiogenesis is not associated with the prognosis of chronic rhinosinusitis with nasal polyposis. Springer Basel AG, 2010 Chronic rhinosinusitis nationallicence Nasal polyposis nationallicence Angiogenesis nationallicence Asthma nationallicence CD34 nationallicence Microvessel density nationallicence Vascular surface density nationallicence Eosinophil nationallicence Antrochoanal polyp nationallicence Middle turbinate nationallicence Hirshoren Nir Department of Otolaryngology/Head and Neck Surgery, Hebrew University School of Medicine, Hadassah Medical Center, Hadassah Ein-Kerem, 91120, Jerusalem, Israel aut Neuman Tzahi Department of Pathology, Hebrew University School of Medicine, Hadassah Medical Center, Jerusalem, Israel aut Gross Menachem Department of Otolaryngology/Head and Neck Surgery, Hebrew University School of Medicine, Hadassah Medical Center, Hadassah Ein-Kerem, 91120, Jerusalem, Israel aut Eliashar Ron Department of Otolaryngology/Head and Neck Surgery, Hebrew University School of Medicine, Hadassah Medical Center, Hadassah Ein-Kerem, 91120, Jerusalem, Israel aut Inflammation Research SP Birkhäuser Verlag Basel 60/4(2011-04-01), 321-327 1023-3830 60:4<321 2011 60 11 https://doi.org/10.1007/s00011-010-0271-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00011-010-0271-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hirshoren Nir Department of Otolaryngology/Head and Neck Surgery, Hebrew University School of Medicine, Hadassah Medical Center, Hadassah Ein-Kerem, 91120, Jerusalem, Israel aut NATIONALLICENCE 700 1- Neuman Tzahi Department of Pathology, Hebrew University School of Medicine, Hadassah Medical Center, Jerusalem, Israel aut NATIONALLICENCE 700 1- Gross Menachem Department of Otolaryngology/Head and Neck Surgery, Hebrew University School of Medicine, Hadassah Medical Center, Hadassah Ein-Kerem, 91120, Jerusalem, Israel aut NATIONALLICENCE 700 1- Eliashar Ron Department of Otolaryngology/Head and Neck Surgery, Hebrew University School of Medicine, Hadassah Medical Center, Hadassah Ein-Kerem, 91120, Jerusalem, Israel aut NATIONALLICENCE 773 0- Inflammation Research SP Birkhäuser Verlag Basel 60/4(2011-04-01), 321-327 1023-3830 60:4<321 2011 60 11 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer