caa a22 4500 445885866 CHVBK 20180317145559.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00011-011-0329-2 doi (NATIONALLICENCE)springer-10.1007/s00011-011-0329-2 Corticotropin-releasing factor family and its receptors: pro-inflammatory or anti-inflammatory targets in the periphery? [Elektronische Daten] [Huayuan Zhu, Juejin Wang, Jianyong Li, Shengnan Li] The corticotropin-releasing factor (CRF) family of neuropeptides is composed of CRF, urocortin 1 (UCN 1), UCN 2 and UCN 3, which can bind to CRF-binding protein (CRF-BP) and two known receptors, CRFR1 and CRFR2, to perform many pathophysiological functions, including inflammation. In contrast to its anti-inflammatory effect in the central nervous system, the roles of the CRF family and its receptors in the periphery are diverse. However, the biological activities of the CRF family in inflammation are circumstantial and remain controversial. It is suggested that this diverse effects of the CRF family may be due to the different types of CRF receptors, different cells and tissues and even different concentrations of CRF family peptides. Though there are difficulties or limitations in establishing the exact modulatory roles of the CRF family and its receptors in peripheral inflammation, the application of CRF receptor agonists or antagonists to treat inflammatory diseases is being pursued with increasing interest. This review describes the effects and mechanisms of the CRF family and its receptors in inflammation; the possible application of CRF receptor agonists or antagonists in inflammatory diseases or disorders will also be discussed. Springer Basel AG, 2011 Corticotropin-releasing factor receptor nationallicence Corticotropin-releasing factor nationallicence Urocortin nationallicence Inflammation nationallicence Zhu Huayuan Department of Haematology, The First Affiliated Hospital of Nanjing Medical University, 210029, Nanjing, China aut Wang Juejin Department of Pharmacology, Nanjing Medical University, 210029, Nanjing, China aut Li Jianyong Department of Haematology, The First Affiliated Hospital of Nanjing Medical University, 210029, Nanjing, China aut Li Shengnan Department of Pharmacology, Nanjing Medical University, 210029, Nanjing, China aut Inflammation Research SP Birkhäuser Verlag Basel 60/8(2011-08-01), 715-721 1023-3830 60:8<715 2011 60 11 https://doi.org/10.1007/s00011-011-0329-2 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00011-011-0329-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zhu Huayuan Department of Haematology, The First Affiliated Hospital of Nanjing Medical University, 210029, Nanjing, China aut NATIONALLICENCE 700 1- Wang Juejin Department of Pharmacology, Nanjing Medical University, 210029, Nanjing, China aut NATIONALLICENCE 700 1- Li Jianyong Department of Haematology, The First Affiliated Hospital of Nanjing Medical University, 210029, Nanjing, China aut NATIONALLICENCE 700 1- Li Shengnan Department of Pharmacology, Nanjing Medical University, 210029, Nanjing, China aut NATIONALLICENCE 773 0- Inflammation Research SP Birkhäuser Verlag Basel 60/8(2011-08-01), 715-721 1023-3830 60:8<715 2011 60 11 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer