caa a22 4500 445885955 CHVBK 20180317145559.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s00011-010-0299-9 doi (NATIONALLICENCE)springer-10.1007/s00011-010-0299-9 Effects of two different dosing regimens of terlipressin on organ functions in ovine endotoxemia [Elektronische Daten] [Matthias Lange, Christian Ertmer, Sebastian Rehberg, Andrea Morelli, Gabriele Köhler, Tim Kampmeier, Hugo Van Aken, Martin Westphal] Objective and design: To test the hypothesis that a continuous infusion of the vasopressin analog terlipressin is associated with less organ dysfunction as compared to intermittent bolus infusion in an ovine sepsis model. Subjects: Twenty-seven adult female sheep. Treatment: All sheep were subjected to a Salmonella typhosa endotoxin infusion (10ng/kg/min). After 16h of endotoxemia, the surviving animals (n=24) were randomized to (1) an untreated control group, (2) a continuous terlipressin group (2mg/24h), or (3) a terlipressin bolus group (1mg/6h). Methods: Hemodynamic variables were measured and blood was withdrawn at specific time points for the assessment of organ functions. Results: Continuous terlipressin infusion was associated with improved surrogate parameters of myocardial, renal, and hepatic function as compared with terlipressin bolus infusion. Reduced vascular hyperpermeability was evidenced by an attenuated decrease in plasma protein concentrations in sheep treated with continuous terlipressin infusion as compared to bolus injection or no treatment. Conclusions: Continuous infusion of low-dose terlipressin preserved several surrogate parameters of organ function better than intermittent bolus injections in sheep with systemic inflammation. Springer Basel AG, 2010 Sepsis nationallicence Sheep nationallicence Vascular leakage nationallicence Arginine vasopressin nationallicence Lange Matthias Department of Anesthesiology and Intensive Care, University of Muenster, Albert-Schweitzer Str. 33, 48149, Muenster, Germany aut Ertmer Christian Department of Anesthesiology and Intensive Care, University of Muenster, Albert-Schweitzer Str. 33, 48149, Muenster, Germany aut Rehberg Sebastian Department of Anesthesiology and Intensive Care, University of Muenster, Albert-Schweitzer Str. 33, 48149, Muenster, Germany aut Morelli Andrea Department of Anesthesiology and Intensive Care, University of Rome "La Sapienza”, Via B. Oriani 2, 00197, Rome, Italy aut Köhler Gabriele Department of Pathology, University of Muenster, Domagkstr. 5, 48149, Muenster, Germany aut Kampmeier Tim Department of Anesthesiology and Intensive Care, University of Muenster, Albert-Schweitzer Str. 33, 48149, Muenster, Germany aut Van Aken Hugo Department of Anesthesiology and Intensive Care, University of Muenster, Albert-Schweitzer Str. 33, 48149, Muenster, Germany aut Westphal Martin Department of Anesthesiology and Intensive Care, University of Muenster, Albert-Schweitzer Str. 33, 48149, Muenster, Germany aut Inflammation Research SP Birkhäuser Verlag Basel 60/5(2011-05-01), 429-437 1023-3830 60:5<429 2011 60 11 https://doi.org/10.1007/s00011-010-0299-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00011-010-0299-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lange Matthias Department of Anesthesiology and Intensive Care, University of Muenster, Albert-Schweitzer Str. 33, 48149, Muenster, Germany aut NATIONALLICENCE 700 1- Ertmer Christian Department of Anesthesiology and Intensive Care, University of Muenster, Albert-Schweitzer Str. 33, 48149, Muenster, Germany aut NATIONALLICENCE 700 1- Rehberg Sebastian Department of Anesthesiology and Intensive Care, University of Muenster, Albert-Schweitzer Str. 33, 48149, Muenster, Germany aut NATIONALLICENCE 700 1- Morelli Andrea Department of Anesthesiology and Intensive Care, University of Rome "La Sapienza”, Via B. Oriani 2, 00197, Rome, Italy aut NATIONALLICENCE 700 1- Köhler Gabriele Department of Pathology, University of Muenster, Domagkstr. 5, 48149, Muenster, Germany aut NATIONALLICENCE 700 1- Kampmeier Tim Department of Anesthesiology and Intensive Care, University of Muenster, Albert-Schweitzer Str. 33, 48149, Muenster, Germany aut NATIONALLICENCE 700 1- Van Aken Hugo Department of Anesthesiology and Intensive Care, University of Muenster, Albert-Schweitzer Str. 33, 48149, Muenster, Germany aut NATIONALLICENCE 700 1- Westphal Martin Department of Anesthesiology and Intensive Care, University of Muenster, Albert-Schweitzer Str. 33, 48149, Muenster, Germany aut NATIONALLICENCE 773 0- Inflammation Research SP Birkhäuser Verlag Basel 60/5(2011-05-01), 429-437 1023-3830 60:5<429 2011 60 11 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer