caa a22 4500 44588598X CHVBK 20180317145559.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s00011-010-0248-7 doi (NATIONALLICENCE)springer-10.1007/s00011-010-0248-7 Gingival crevicular fluid IL-6, tPA, PAI-2, albumin levels following initial periodontal treatment in chronic periodontitis patients with or without type 2 diabetes [Elektronische Daten] [Levent Kardeşler, Nurcan Buduneli, Şevki Çetinkalp, David Lappin, Denis Kinane] Objectives: To evaluate initial periodontal treatment effects on gingival crevicular fluid (GCF) interleukin-6 (IL-6), tissue-type plasminogen activator (tPA), plasminogen activator inhibitor-2 (PAI-2), albumin levels in type 2 diabetic patients. Design and methods: GCF samples were collected from 20 type 2 diabetic, 22 non-diabetic non-smokers all with chronic periodontitis at baseline, 1-, 3-months following initial periodontal treatment. Biochemical analysis was performed by ELISA. Data were tested by Mann-Whitney U, Wilcoxon tests. Results: The total amounts of albumin, IL-6, tPA, PAI-2 decreased significantly in diabetics after treatment (1- and 3-months) whereas, only PAI-2 decreased in non-diabetic group at 3-months (p<0.05). There were statistically significant differences between the diabetics and non-diabetics at all time points for albumin, PAI-2 and at 1-, 3-months for GCF volume (p<0.050) but only at baseline for IL-6 (p<0.050). Conclusion: Present data suggest clinical improvements are less apparent in diabetic chronic periodontitis patients as reflected by disease markers in GCF and by an increase in concentrations of inflammatory proteins IL-6, tPA, and PAI-2 in GCF of this patient group following initial periodontal treatment. Springer Basel AG, 2010 Diabetes mellitus nationallicence ELISA nationallicence Gingival crevicular fluid nationallicence IL-6 nationallicence Plasminogen activators nationallicence Periodontal disease nationallicence Kardeşler Levent Department of Periodontology, School of Dentistry, Ege University, 35100, Bornova, İzmir, Turkey aut Buduneli Nurcan Department of Periodontology, School of Dentistry, Ege University, 35100, Bornova, İzmir, Turkey aut Çetinkalp Şevki Department of Metabolic Diseases and Endocrinology, School of Medicine, Ege University, İzmir, Turkey aut Lappin David Infection and Immunity Group, Glasgow Dental School, School of Medicine, University of Glasgow, Glasgow, UK aut Kinane Denis Department of Periodontology, School of Dentistry, University of Louisville, Louisville, KY, USA aut Inflammation Research SP Birkhäuser Verlag Basel 60/2(2011-02-01), 143-151 1023-3830 60:2<143 2011 60 11 https://doi.org/10.1007/s00011-010-0248-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00011-010-0248-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kardeşler Levent Department of Periodontology, School of Dentistry, Ege University, 35100, Bornova, İzmir, Turkey aut NATIONALLICENCE 700 1- Buduneli Nurcan Department of Periodontology, School of Dentistry, Ege University, 35100, Bornova, İzmir, Turkey aut NATIONALLICENCE 700 1- Çetinkalp Şevki Department of Metabolic Diseases and Endocrinology, School of Medicine, Ege University, İzmir, Turkey aut NATIONALLICENCE 700 1- Lappin David Infection and Immunity Group, Glasgow Dental School, School of Medicine, University of Glasgow, Glasgow, UK aut NATIONALLICENCE 700 1- Kinane Denis Department of Periodontology, School of Dentistry, University of Louisville, Louisville, KY, USA aut NATIONALLICENCE 773 0- Inflammation Research SP Birkhäuser Verlag Basel 60/2(2011-02-01), 143-151 1023-3830 60:2<143 2011 60 11 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer