caa a22 4500 445886021 CHVBK 20180317145600.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s00011-010-0247-8 doi (NATIONALLICENCE)springer-10.1007/s00011-010-0247-8 Lack of association between plasma myeloperoxidase levels and angiographic severity of coronary artery disease in patients with acute coronary syndrome [Elektronische Daten] [Eraldo de Azevedo Lucio, Sandro Gonçalves, Jorge Ribeiro, Gilberto Nunes, Jarbas de Oliveira, Gustavo Araujo, Marco Wainstein] Objective: To evaluate the association between plasma myeloperoxidase (MPO) levels and angiographic severity of coronary atherosclerotic lesions in patients with non-ST elevation acute coronary syndrome (ACS). Design and methods: This cross-sectional study examined high-risk ACS patients who underwent coronary angiography within 72h of the onset of symptoms by measuring their plasma MPO levels after sheath insertion. Gensini score was used to evaluate angiographic severity of coronary artery disease. Results: A total of 48 patients were included in the study. Median MPO levels and Gensini scores were 6.9ng/mL (4.4-73.5ng/mL) and 10 (0-87.5), respectively. Spearman's correlation coefficient did not show a significant association between MPO levels and Gensini scores (r s=0.2; p=0.177). There was no correlation between MPO and age, hypertension, diabetes, leukocyte count, troponin I, CK-MB ≥2×ULN (upper limit of normal), TIMI risk score ≥4 and Gensini score in the multivariate analysis. Conclusion: Our findings indicate that MPO expression is not associated with anatomical severity of coronary lesions in ACS. Springer Basel AG, 2010 Atherosclerosis nationallicence Inflammation nationallicence Biomarkers nationallicence de Azevedo Lucio Eraldo Post-graduate Program in Cardiology, Faculty of Medicine, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos 2350, CEP 90035-003, Porto Alegre, RS, Brazil aut Gonçalves Sandro Post-graduate Program in Cardiology, Faculty of Medicine, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos 2350, CEP 90035-003, Porto Alegre, RS, Brazil aut Ribeiro Jorge Post-graduate Program in Cardiology, Faculty of Medicine, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos 2350, CEP 90035-003, Porto Alegre, RS, Brazil aut Nunes Gilberto Post-graduate Program in Cardiology, Faculty of Medicine, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos 2350, CEP 90035-003, Porto Alegre, RS, Brazil aut de Oliveira Jarbas Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil aut Araujo Gustavo Cardiology Division, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil aut Wainstein Marco Post-graduate Program in Cardiology, Faculty of Medicine, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos 2350, CEP 90035-003, Porto Alegre, RS, Brazil aut Inflammation Research SP Birkhäuser Verlag Basel 60/2(2011-02-01), 137-142 1023-3830 60:2<137 2011 60 11 https://doi.org/10.1007/s00011-010-0247-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00011-010-0247-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- de Azevedo Lucio Eraldo Post-graduate Program in Cardiology, Faculty of Medicine, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos 2350, CEP 90035-003, Porto Alegre, RS, Brazil aut NATIONALLICENCE 700 1- Gonçalves Sandro Post-graduate Program in Cardiology, Faculty of Medicine, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos 2350, CEP 90035-003, Porto Alegre, RS, Brazil aut NATIONALLICENCE 700 1- Ribeiro Jorge Post-graduate Program in Cardiology, Faculty of Medicine, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos 2350, CEP 90035-003, Porto Alegre, RS, Brazil aut NATIONALLICENCE 700 1- Nunes Gilberto Post-graduate Program in Cardiology, Faculty of Medicine, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos 2350, CEP 90035-003, Porto Alegre, RS, Brazil aut NATIONALLICENCE 700 1- de Oliveira Jarbas Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil aut NATIONALLICENCE 700 1- Araujo Gustavo Cardiology Division, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil aut NATIONALLICENCE 700 1- Wainstein Marco Post-graduate Program in Cardiology, Faculty of Medicine, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos 2350, CEP 90035-003, Porto Alegre, RS, Brazil aut NATIONALLICENCE 773 0- Inflammation Research SP Birkhäuser Verlag Basel 60/2(2011-02-01), 137-142 1023-3830 60:2<137 2011 60 11 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer