caa a22 4500 445886099 CHVBK 20180317145600.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s00011-010-0261-x doi (NATIONALLICENCE)springer-10.1007/s00011-010-0261-x Anti-inflammatory defense mechanisms of Entamoeba histolytica [Elektronische Daten] [Raúl Silva-García, Guadalupe Rico-Rosillo] The monocyte locomotion inhibitory factor (MLIF), a heat-stable oligopeptide found in the supernatant fluid of Entamoeba histolytica axenic cultures, may contribute to the delayed inflammation observed in amoebic hepatic abscess. This factor was isolated by ultra-filtration and high powered liquid chromatography, obtaining a primary Met-Gln-Cys-Asn-Ser structure, identified afterwards as the carboxyl-terminal (...Cys-Asn-Ser) active site. The selective anti-inflammatory effects of the pentapeptide have been observed in both in vitro and in vivo models, using a synthetic pentapeptide to maintain the same anti-inflammatory conditions during the experimental assays. Anti-inflammatory effects observed include inhibition of human monocyte locomotion and the respiratory burst in monocytes and neutrophils, increasing expression of anti-inflammatory cytokines and inhibiting expression of the adhesion molecules VLA-4 and VCAM, among others. In this review, we will describe the effects of MLIF detected so far and how it might be used as a therapeutical agent against inflammatory diseases. Springer Basel AG, 2010 In vivo inflammation nationallicence Wound healing nationallicence Leukocyte migration nationallicence Macrophages nationallicence NF-κB nationallicence Silva-García Raúl Unidad de Investigación Médica en Inmunología, Hospital de Pediatría, CMN-Siglo XXI, Avenida Cuauhtémoc #330, CP. 06720, México, D.F., México aut Rico-Rosillo Guadalupe División de Investigación, Facultad de Medicina UNAM, Av. Universidad 3000 circuito escolar s/n, Col. Copilco, Delegación Coyoacán, C.P. 04510, México, D.F., México aut Inflammation Research SP Birkhäuser Verlag Basel 60/2(2011-02-01), 111-117 1023-3830 60:2<111 2011 60 11 https://doi.org/10.1007/s00011-010-0261-x text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00011-010-0261-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Silva-García Raúl Unidad de Investigación Médica en Inmunología, Hospital de Pediatría, CMN-Siglo XXI, Avenida Cuauhtémoc #330, CP. 06720, México, D.F., México aut NATIONALLICENCE 700 1- Rico-Rosillo Guadalupe División de Investigación, Facultad de Medicina UNAM, Av. Universidad 3000 circuito escolar s/n, Col. Copilco, Delegación Coyoacán, C.P. 04510, México, D.F., México aut NATIONALLICENCE 773 0- Inflammation Research SP Birkhäuser Verlag Basel 60/2(2011-02-01), 111-117 1023-3830 60:2<111 2011 60 11 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer