caa a22 4500 445886102 CHVBK 20180317145600.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s00011-011-0368-8 doi (NATIONALLICENCE)springer-10.1007/s00011-011-0368-8 Associations between cytotoxic T lymphocyte-associated antigen-4 polymorphisms and serum tumor necrosis factor-α and interferon-γ levels in patients with chronic hepatitis B virus infection [Elektronische Daten] [Qunying Han, Shaoqiong Duan, Guoyu Zhang, Zhu Li, Na Li, Qianqian Zhu, Yi Lv, Jinghong Chen, Zhengwen Liu] Background: Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) polymorphism, which may affect host immune response including cytokines production, is thought to be associated with hepatitis B virus (HBV) infection. This study investigated the associations between CTLA4 polymorphism and serum tumor necrosis factor (TNF)-α and interferon (IFN)-γ levels in patients with chronic HBV infection. Methods: CTLA4 promoter −318C/T and exon 1 +49A/G polymorphisms and serum TNF-α and IFN-γ levels were determined in 172 patients with chronic HBV infection and 145 healthy controls. Results: The genotype of CTLA4 −318C/T polymorphism had no association to TNF-α and IFN-γ levels. Serum levels of TNF-α and IFN-γ in chronic HBV patients with +49GG genotype were lower than those with +49AG genotype (p=0.030 and p=0.042, respectively), and haplotypes −318C+49A and −318C+49G seemed to have no significant effects on TNF-α and IFN-γ levels. Conclusions: CTLA4 +49GG genotype was associated to lower TNF-α and IFN-γ levels in patients with chronic HBV infection but this association was diminished by haplotype formation with −318C/T alleles, indicating that the influence of CTLA4 −318C/T and +49A/G polymorphisms on the susceptibility and disease progress of chronic HBV infection may not be effectuated by affecting TNF-α and IFN-γ secretion. Springer Basel AG, 2011 Chronic HBV infection nationallicence Cytotoxic T lymphocyte-associated antigen 4 nationallicence Genetic polymorphism nationallicence Tumor necrosis factor-α nationallicence Interferon-γ nationallicence Han Qunying Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, 710061, Xi' an, Shaanxi, People's Republic of China aut Duan Shaoqiong Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, 710061, Xi' an, Shaanxi, People's Republic of China aut Zhang Guoyu Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, 710061, Xi' an, Shaanxi, People's Republic of China aut Li Zhu Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, 710061, Xi' an, Shaanxi, People's Republic of China aut Li Na Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, 710061, Xi' an, Shaanxi, People's Republic of China aut Zhu Qianqian Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, 710061, Xi' an, Shaanxi, People's Republic of China aut Lv Yi Department of Hepatobiliary Surgery, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, 710061, Xi'an, Shaanxi, People's Republic of China aut Chen Jinghong Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, School of Medicine, Institute of Endemic Diseases, Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China aut Liu Zhengwen Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, 710061, Xi' an, Shaanxi, People's Republic of China aut Inflammation Research SP Birkhäuser Verlag Basel 60/11(2011-11-01), 1071-1078 1023-3830 60:11<1071 2011 60 11 https://doi.org/10.1007/s00011-011-0368-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00011-011-0368-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Han Qunying Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, 710061, Xi' an, Shaanxi, People's Republic of China aut NATIONALLICENCE 700 1- Duan Shaoqiong Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, 710061, Xi' an, Shaanxi, People's Republic of China aut NATIONALLICENCE 700 1- Zhang Guoyu Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, 710061, Xi' an, Shaanxi, People's Republic of China aut NATIONALLICENCE 700 1- Li Zhu Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, 710061, Xi' an, Shaanxi, People's Republic of China aut NATIONALLICENCE 700 1- Li Na Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, 710061, Xi' an, Shaanxi, People's Republic of China aut NATIONALLICENCE 700 1- Zhu Qianqian Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, 710061, Xi' an, Shaanxi, People's Republic of China aut NATIONALLICENCE 700 1- Lv Yi Department of Hepatobiliary Surgery, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, 710061, Xi'an, Shaanxi, People's Republic of China aut NATIONALLICENCE 700 1- Chen Jinghong Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, School of Medicine, Institute of Endemic Diseases, Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China aut NATIONALLICENCE 700 1- Liu Zhengwen Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, 710061, Xi' an, Shaanxi, People's Republic of China aut NATIONALLICENCE 773 0- Inflammation Research SP Birkhäuser Verlag Basel 60/11(2011-11-01), 1071-1078 1023-3830 60:11<1071 2011 60 11 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer