caa a22 4500 445886110 CHVBK 20180317145600.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s00011-011-0374-x doi (NATIONALLICENCE)springer-10.1007/s00011-011-0374-x Associations between ERAP1 polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis [Elektronische Daten] [Young Lee, Sung Choi, Jong Ji, Gwan Song] Objective: The aim of this study was to determine whether five polymorphisms of endoplasmic reticulum aminopeptidase 1 (ERAP1) confer susceptibility to ankylosing spondylitis (AS). Methods: The authors conducted five types of meta-analysis on the associations between the rs27044, rs17482078, rs10050860, rs30187, and rs2287987 polymorphisms of ERAP1 and AS susceptibility, using fixed and random effects models. Results: Six studies were included in this meta-analysis, which in total involved 4,594 AS patients and 3,971 controls, five European populations, and one Asian population. Meta-analysis identified a significant association between AS and the two alleles of the rs27044 polymorphism in all study subjects [odds ratio (OR)=1.333, 95% confidence interval (CI)=1.102-1.612, p=0.003]. Stratification by ethnicity identified a significant association between this polymorphism and AS in Europeans (OR=1.281, 95% CI=1.032-1.588, p=0.024) and in Asians (OR=1.554, 95% CI=1.313-1.838, p=2×10−8), and meta-analysis of the rs30187 polymorphism showed the same pattern. Furthermore, analysis revealed significant associations between the two alleles of the rs17482078, rs10050860, and rs2287987 polymorphisms and the risk of developing AS in Europeans (OR=0.726, 95% CI=0.655-0.805, p<1×10−10; OR=0.724, 95% CI=0.665-0.787, p<1×10−10; OR=0.708, 95% CI=0.639-0.784, p<1×10−10, respectively). However, the single Asian study included showed no association between the rs17482078, rs30187, and rs2287987 polymorphisms and AS. Conclusions: This meta-analysis shows that the rs27044, rs17482078, rs10050860, rs30187, and rs2287987 polymorphisms of ERAP1 are associated with the development of AS in Europeans. However, further study of this association is required in other ethnic groups. Springer Basel AG, 2011 ERAP1 nationallicence Polymorphism nationallicence Ankylosing spondylitis nationallicence Meta-analysis nationallicence Lee Young Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126-1 Anam-dong 5 ga, Seongbuk-gu, 136-705, Seoul, Korea aut Choi Sung Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126-1 Anam-dong 5 ga, Seongbuk-gu, 136-705, Seoul, Korea aut Ji Jong Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126-1 Anam-dong 5 ga, Seongbuk-gu, 136-705, Seoul, Korea aut Song Gwan Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126-1 Anam-dong 5 ga, Seongbuk-gu, 136-705, Seoul, Korea aut Inflammation Research SP Birkhäuser Verlag Basel 60/11(2011-11-01), 999-1003 1023-3830 60:11<999 2011 60 11 https://doi.org/10.1007/s00011-011-0374-x text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00011-011-0374-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lee Young Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126-1 Anam-dong 5 ga, Seongbuk-gu, 136-705, Seoul, Korea aut NATIONALLICENCE 700 1- Choi Sung Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126-1 Anam-dong 5 ga, Seongbuk-gu, 136-705, Seoul, Korea aut NATIONALLICENCE 700 1- Ji Jong Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126-1 Anam-dong 5 ga, Seongbuk-gu, 136-705, Seoul, Korea aut NATIONALLICENCE 700 1- Song Gwan Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126-1 Anam-dong 5 ga, Seongbuk-gu, 136-705, Seoul, Korea aut NATIONALLICENCE 773 0- Inflammation Research SP Birkhäuser Verlag Basel 60/11(2011-11-01), 999-1003 1023-3830 60:11<999 2011 60 11 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer