caa a22 4500 445887648 CHVBK 20180317145604.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s00535-010-0300-y doi (NATIONALLICENCE)springer-10.1007/s00535-010-0300-y Evaluation of new subclassification of type VI pit pattern for determining the depth and type of invasion of colorectal neoplasm [Elektronische Daten] [Kenshi Matsumoto, Akihito Nagahara, Takeshi Terai, Hiroya Ueyama, Hideaki Ritsuno, Hiroki Mori, Kohsaburo Nakae, Kazuko Beppu, Tomoyoshi Shibuya, Naoto Sakamoto, Taro Osada, Tatsuo Ogihara, Takashi Yao, Sumio Watanabe] Background: Colorectal neoplasms with a type VI pit pattern include various lesions, such as adenomas, intramucosal cancers, and submucosal carcinomas. Methods: We analyzed 96 colorectal neoplasms with a type VI pit pattern and identified six different variants: (1) unclear outline of the pit; (2) irregular margins of the pit; (3) narrowing of the pit; (4) ragged array of the pit; (5) high residual density of the pit; (6) abnormal branching of the pit. We examined the relationship between the appearance of each VI pit pattern and histology, including the depth of invasion. Results: In univariate logistic regression analysis the unclear outline, irregular margins, and narrowing of the pit were significantly associated with a submucosal (SM) invasion ≥1000μm (P<0.01). In multivariate logistic regression analysis, unclear outline of the pit was shown to be the only significant predictor of highly invasive submucosal cancer (odds ratio=24.20, P<0.0001). Regarding tumor morphology, the following were significantly associated with an SM invasion ≥1000μm: in protruded type, ragged array (P=0.022), irregular margins of the pit (P=0.011), and unclear outline of the pit (P<0.01); in flat type, irregular margins of the pit (P<0.01) and unclear outline of the pit (P<0.01); and in the depressed type, narrowing of the pit (P=0.015) and unclear outline of the pit (P<0.01). Conclusions: Subclassification of the type VI pit pattern is useful for determining the depth of invasion of colorectal neoplasms. Springer, 2010 Magnifying chromoendoscopy nationallicence Colon cancer nationallicence Colonoscopy nationallicence Matsumoto Kenshi Department of Gastroenterology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan aut Nagahara Akihito Department of Gastroenterology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan aut Terai Takeshi Department of Gastroenterology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan aut Ueyama Hiroya Department of Gastroenterology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan aut Ritsuno Hideaki Department of Gastroenterology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan aut Mori Hiroki Department of Gastroenterology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan aut Nakae Kohsaburo Department of Gastroenterology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan aut Beppu Kazuko Department of Gastroenterology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan aut Shibuya Tomoyoshi Department of Gastroenterology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan aut Sakamoto Naoto Department of Gastroenterology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan aut Osada Taro Department of Gastroenterology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan aut Ogihara Tatsuo Department of Gastroenterology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan aut Yao Takashi Department of Human Pathology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan aut Watanabe Sumio Department of Gastroenterology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan aut Journal of Gastroenterology Springer Japan 46/1(2011-01-01), 31-38 0944-1174 46:1<31 2011 46 535 https://doi.org/10.1007/s00535-010-0300-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-010-0300-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Matsumoto Kenshi Department of Gastroenterology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan aut NATIONALLICENCE 700 1- Nagahara Akihito Department of Gastroenterology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan aut NATIONALLICENCE 700 1- Terai Takeshi Department of Gastroenterology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan aut NATIONALLICENCE 700 1- Ueyama Hiroya Department of Gastroenterology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan aut NATIONALLICENCE 700 1- Ritsuno Hideaki Department of Gastroenterology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan aut NATIONALLICENCE 700 1- Mori Hiroki Department of Gastroenterology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan aut NATIONALLICENCE 700 1- Nakae Kohsaburo Department of Gastroenterology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan aut NATIONALLICENCE 700 1- Beppu Kazuko Department of Gastroenterology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan aut NATIONALLICENCE 700 1- Shibuya Tomoyoshi Department of Gastroenterology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan aut NATIONALLICENCE 700 1- Sakamoto Naoto Department of Gastroenterology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan aut NATIONALLICENCE 700 1- Osada Taro Department of Gastroenterology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan aut NATIONALLICENCE 700 1- Ogihara Tatsuo Department of Gastroenterology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan aut NATIONALLICENCE 700 1- Yao Takashi Department of Human Pathology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan aut NATIONALLICENCE 700 1- Watanabe Sumio Department of Gastroenterology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/1(2011-01-01), 31-38 0944-1174 46:1<31 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer