caa a22 4500 445887680 CHVBK 20180317145604.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s00535-010-0307-4 doi (NATIONALLICENCE)springer-10.1007/s00535-010-0307-4 A population-based cohort study for the risk factors of HCC among hepatitis B virus mono-infected subjects in Japan [Elektronische Daten] [Atsunori Kusakabe, Yasuhito Tanaka, Manami Inoue, Fuat Kurbanov, Kanako Tatematsu, Shunsuke Nojiri, Takashi Joh, Shoichiro Tsugane, Masashi Mizokami] Background: There have only been a few prospective studies investigating risk factors associated with the development of hepatocellular carcinoma (HCC) among chronic hepatitis B patients all over the world, and no study has been conducted in Japanese population. Methods: A population-based cohort consisting of 19393 subjects (middle aged or older) with over 13years' follow-up was investigated in Japan. Results: Of 19393 subjects, 479 had hepatitis B virus (HBV) mono-infection (2.5%). During the 245923 person-years' follow-up (average follow-up period 12.7years), 13 cases of newly diagnosed HCC were documented in the HBV mono-infected group. Several factors at baseline (male, smoking, alanine aminotransferase, the positivity of HBe antigen and HB core-related antigen, the proportion of HBV DNA≥5 log copies/mL, T1753V mutation, and A1762T/G1764A double mutation) were significantly associated with HCC among HBV mono-infected subjects. Multivariate-adjusted Cox hazard model showed that A1762T/G1764A (hazard ratio 7.05 [95% confidence interval (CI) 1.03-48.12, P=0.046]) was the only independent risk factor for the development of HCC. Kaplan-Meier method also showed that the probability of HCC occurrence-free was significantly lower in HBV mono-infected subjects with A1762T/G1764A double mutation than those without these mutations. Conclusion: HBV mono-infected subjects with A1762T/G1764A double mutation could be at high risk of HCC development during the natural course of HBV infection. Springer, 2010 Hepatitis B virus nationallicence Hepatocellular carcinoma nationallicence Risk factor nationallicence Japan nationallicence Kusakabe Atsunori Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan aut Tanaka Yasuhito Department of Virology and Liver Unit, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho, 467-8601, Nagoya, Japan aut Inoue Manami Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan aut Kurbanov Fuat Department of Virology and Liver Unit, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho, 467-8601, Nagoya, Japan aut Tatematsu Kanako Department of Virology and Liver Unit, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho, 467-8601, Nagoya, Japan aut Nojiri Shunsuke Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan aut Joh Takashi Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan aut Tsugane Shoichiro Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan aut Mizokami Masashi The Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine, Ichikawa, Japan aut Journal of Gastroenterology Springer Japan 46/1(2011-01-01), 117-124 0944-1174 46:1<117 2011 46 535 https://doi.org/10.1007/s00535-010-0307-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-010-0307-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kusakabe Atsunori Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan aut NATIONALLICENCE 700 1- Tanaka Yasuhito Department of Virology and Liver Unit, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho, 467-8601, Nagoya, Japan aut NATIONALLICENCE 700 1- Inoue Manami Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan aut NATIONALLICENCE 700 1- Kurbanov Fuat Department of Virology and Liver Unit, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho, 467-8601, Nagoya, Japan aut NATIONALLICENCE 700 1- Tatematsu Kanako Department of Virology and Liver Unit, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho, 467-8601, Nagoya, Japan aut NATIONALLICENCE 700 1- Nojiri Shunsuke Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan aut NATIONALLICENCE 700 1- Joh Takashi Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan aut NATIONALLICENCE 700 1- Tsugane Shoichiro Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan aut NATIONALLICENCE 700 1- Mizokami Masashi The Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine, Ichikawa, Japan aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/1(2011-01-01), 117-124 0944-1174 46:1<117 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer