caa a22 4500 445887699 CHVBK 20180317145604.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s00535-010-0295-4 doi (NATIONALLICENCE)springer-10.1007/s00535-010-0295-4 A Japanese case series of 12 patients with esophageal eosinophilia [Elektronische Daten] [Yasuhiko Abe, Katsunori Iijima, Shuichi Ohara, Tomoyuki Koike, Nobuyuki Ara, Kaname Uno, Naoki Asano, Akira Imatani, Katsuaki Kato, Daisuke Shibuya, Tooru Shimosegawa] Background: Eosinophilic esophagitis (EoE) has been a rarely recognized condition in Asian populations, and its clinical manifestation is rarely documented. Our aim was to describe clinically, endoscopically, and pathologically the features of patients with esophageal eosinophilia, including EoE. Methods: Twelve patients histologically proven to have esophageal eosinophilia were investigated. The histological diagnostic cutoff value was defined as a peak of ≥15 eosinophils/high-power field (HPF) in esophageal biopsies. Symptoms, endoscopic and pathological findings, and treatment outcome were evaluated. Results: Nine of the 12 patients were male and the 12 patients had a mean age of 47.7years. Allergic conditions were concurrent in a total of 3 patients. Mild peripheral eosinophilia was observed in only 2 patients. The predominant symptom was solid-food dysphagia, but some patients complained of heartburn, or chest, epigastric, or back pain. Three asymptomatic subjects were also incidentally diagnosed during endoscopic screening. Linear furrows, concentric rings, and white exudates in the esophagus were frequently observed. In 4 of 5 patients who were administered a proton pump inhibitor (PPI), esophageal eosinophilia was histologically decreased or disappeared with symptom relief and endoscopic improvement. In 2 patients unresponsive to PPI, topical steroid therapy, administered by the swallowing of fluticasone propionate, led to symptomatic and histological remission. Conclusions: The endoscopic recognition of linear furrows, concentric rings, and white exudates is important in the diagnosis of eosinophilic esophageal inflammation. In a subset of patients this condition improves clinicopathologically with PPI treatment, and typical EoE, as strictly defined by unresponsiveness to PPI, appears to be a rather rare condition. Springer, 2010 Esophageal eosinophilia nationallicence Eosinophilic esophagitis nationallicence Proton pump inhibitor nationallicence Topical steroid therapy nationallicence EoE : Eosinophilic esophagitis nationallicence HPF : High-power field nationallicence PPI : Proton pump inhibitor nationallicence FP : Fluticasone propionate nationallicence Abe Yasuhiko Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, 980-8574, Sendai, Miyagi, Japan aut Iijima Katsunori Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, 980-8574, Sendai, Miyagi, Japan aut Ohara Shuichi Department of Gastroenterology, Tohoku Rousai Hospital, Sendai, Miyagi, Japan aut Koike Tomoyuki Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, 980-8574, Sendai, Miyagi, Japan aut Ara Nobuyuki Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, 980-8574, Sendai, Miyagi, Japan aut Uno Kaname Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, 980-8574, Sendai, Miyagi, Japan aut Asano Naoki Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, 980-8574, Sendai, Miyagi, Japan aut Imatani Akira Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, 980-8574, Sendai, Miyagi, Japan aut Kato Katsuaki Cancer Detection Center, Miyagi Cancer Society, Sendai, Miyagi, Japan aut Shibuya Daisuke Cancer Detection Center, Miyagi Cancer Society, Sendai, Miyagi, Japan aut Shimosegawa Tooru Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, 980-8574, Sendai, Miyagi, Japan aut Journal of Gastroenterology Springer Japan 46/1(2011-01-01), 25-30 0944-1174 46:1<25 2011 46 535 https://doi.org/10.1007/s00535-010-0295-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-010-0295-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Abe Yasuhiko Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, 980-8574, Sendai, Miyagi, Japan aut NATIONALLICENCE 700 1- Iijima Katsunori Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, 980-8574, Sendai, Miyagi, Japan aut NATIONALLICENCE 700 1- Ohara Shuichi Department of Gastroenterology, Tohoku Rousai Hospital, Sendai, Miyagi, Japan aut NATIONALLICENCE 700 1- Koike Tomoyuki Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, 980-8574, Sendai, Miyagi, Japan aut NATIONALLICENCE 700 1- Ara Nobuyuki Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, 980-8574, Sendai, Miyagi, Japan aut NATIONALLICENCE 700 1- Uno Kaname Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, 980-8574, Sendai, Miyagi, Japan aut NATIONALLICENCE 700 1- Asano Naoki Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, 980-8574, Sendai, Miyagi, Japan aut NATIONALLICENCE 700 1- Imatani Akira Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, 980-8574, Sendai, Miyagi, Japan aut NATIONALLICENCE 700 1- Kato Katsuaki Cancer Detection Center, Miyagi Cancer Society, Sendai, Miyagi, Japan aut NATIONALLICENCE 700 1- Shibuya Daisuke Cancer Detection Center, Miyagi Cancer Society, Sendai, Miyagi, Japan aut NATIONALLICENCE 700 1- Shimosegawa Tooru Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, 980-8574, Sendai, Miyagi, Japan aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/1(2011-01-01), 25-30 0944-1174 46:1<25 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer